Axonal and perikaryal involvement in chronic inflammatory demyelinating polyneuropathy

• Published in: Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1999-06, Vol.66 (6), p.727-733
• Main Authors: Nagamatsu, M, Terao, S, Misu, K, Li, M, Hattori, N, Ichimura, M, Sakai, M, Yamamoto, H, Watanabe, H, Riku, S, Ikeda, E, Hata, J, Oda, M, Satake, M, Nakamura, N, Matsuya, S, Hashizume, Y, Sobue, G
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; axon loss; Biological and medical sciences; Biopsy; Cardiovascular disease; Child; Child, Preschool; chronic inflammatory demyelinating polyneuropathy; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction; Demyelinating Diseases - pathology; Disability; Edema; Female; Hospitals; Humans; Inflammation - pathology; Lifestyles; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Neurons; Pathology; Patients; Peripheral Nervous System Diseases - pathology; Pneumonia; Spinal cord; Spinal Cord - pathology; spinal motor neuron; Sural Nerve - pathology
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp.66.6.727

OBJECTIVES To assess the extent of loss of myelinated nerve fibres and spinal motor neuron loss in chronic inflammatory demyelinating polyneuropathy (CIDP), a clinicopathological study was conducted on biopsied sural nerves and necropsied spinal cords from patients with CIDP. METHODS The myelinated fibre pathology of 71 biopsied sural nerves and motor neuron pathology of nine necropsied spinal cords at L4 levels in patients with CIDP were quantitatively and immunohistochemically assessed. RESULTS Myelinated nerve fibre density was significantly diminished to 65.4% of the control values (p