Pattern of dopaminergic loss in the striatum of humans with parkinsonism induced by MPTP

The report by Calne et al of low18F-fluorodopa uptake in subjects who had been exposed to MPTP but were clinically well, demonstrated the potential of18Ffluorodopa positron emission tomography (PET) scanning as a marker of subclinical dopaminergic cell loss. 2 Some others who escaped parkinsonism in...

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Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2000-03, Vol.68 (3), p.276-276
Main Author: SAWLE, G V
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects
Cell Death - physiology
Corpus Striatum - pathology
Corpus Striatum - physiopathology
Dopamine - physiology
Humans
Neurons - pathology
Neurons - physiology
Parkinson Disease, Secondary - etiology
Parkinson Disease, Secondary - pathology
Parkinson Disease, Secondary - physiopathology
Parkinson's disease
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Summary:The report by Calne et al of low18F-fluorodopa uptake in subjects who had been exposed to MPTP but were clinically well, demonstrated the potential of18Ffluorodopa positron emission tomography (PET) scanning as a marker of subclinical dopaminergic cell loss. 2 Some others who escaped parkinsonism in the aftermath of their exposure have gone on to develop clinical parkinsonism years later. 3 A few incapacitated patients underwent fetal cell implantation and their outcome data have been published. 4 In this issue, pp 313-316 , Snow et al 5 report 18F-fluorodopa PET data from nine subjects who were exposed to MPTP about 10 years earlier, eight of whom developed mild parkinsonism.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.68.3.276