Increased plasma neurotensin concentrations in patients with Parkinson's disease

Plasma neurotensin (NT) was measured by radioimmunoassay in propanol extracted and unextracted plasma from 16 parkinsonian patients (four before treatment) and 16 age and sex matched controls. Mean plasma NT concentrations were consistently higher in parkinsonian patients than in controls and higher...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2001-06, Vol.70 (6), p.784-786
Main Authors: Schimpff, R-M, Avard, C, Fénelon, G, Lhiaubet, A-M, Tennezé, L, Vidailhet, M, Rostène, W
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chromatography, Liquid - methods
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnosis
dopamine
Female
Humans
Male
Medical sciences
Middle Aged
Neurology
Neuropeptides
Neurotensin - blood
Parkinson Disease - blood
Parkinson's disease
plasma neurotensin
Short Report
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Summary:Plasma neurotensin (NT) was measured by radioimmunoassay in propanol extracted and unextracted plasma from 16 parkinsonian patients (four before treatment) and 16 age and sex matched controls. Mean plasma NT concentrations were consistently higher in parkinsonian patients than in controls and higher in the four untreated patients than in levodopa treated patients suggesting that plasma NT measurement may represent an easy detectable additional index in diagnosing parkinsonism and provides a novel approach to research in this field.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.70.6.784