Mood changes with deep brain stimulation of STN and GPi: results of a pilot study

The results of this study suggest that there are mood changes associated with deep brain stimulation of the subthalamic nucleus (STN) and the globus pallidus interna (GPi). Further, optimal placement of electrodes in both STN and GPi seems to result in overall improvement in mood and is associated w...

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Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2003-11, Vol.74 (11), p.1584-1586
Main Authors: Okun, M S, Green, J, Saben, R, Gross, R, Foote, K D, Vitek, J L
Format: Article
Language:English
Subjects:
Affective disorders
Aged
Anxiety
Apathy
Biological and medical sciences
Brain
Brain stimulation
Causes of
cognition
Cognition & reasoning
deep brain stimulation
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dopamine
Electric Stimulation Therapy - adverse effects
Emotions
Female
Geriatrics
Globus Pallidus - pathology
Globus Pallidus - physiology
globus pallidus interna
Humans
Influence
Male
Medical sciences
Mental depression
Middle Aged
Mood Disorders - etiology
Neurology
Parkinson Disease - therapy
Parkinson's disease
Physiological aspects
Short Report
Statistics
Studies
Substance abuse treatment
subthalamic nucleus
Subthalamic Nucleus - pathology
Subthalamic Nucleus - physiology
Thalamus
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container_end_page 1586
container_issue 11
container_start_page 1584
container_title Journal of neurology, neurosurgery and psychiatry
container_volume 74
creator Okun, M S
Green, J
Saben, R
Gross, R
Foote, K D
Vitek, J L
description The results of this study suggest that there are mood changes associated with deep brain stimulation of the subthalamic nucleus (STN) and the globus pallidus interna (GPi). Further, optimal placement of electrodes in both STN and GPi seems to result in overall improvement in mood and is associated with a lower incidence of adverse mood effects than stimulation outside the optimal site. Preliminary data from this study, however, suggest that slight movement dorsal or ventral to the site of optimal motor performance may be associated with more adverse changes in mood with STN stimulation than with GPi stimulation.
doi_str_mv 10.1136/jnnp.74.11.1584
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source NCBI_PubMed Central（免费）
subjects Affective disorders
Aged
Anxiety
Apathy
Biological and medical sciences
Brain
Brain stimulation
Causes of
cognition
Cognition & reasoning
deep brain stimulation
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dopamine
Electric Stimulation Therapy - adverse effects
Emotions
Female
Geriatrics
Globus Pallidus - pathology
Globus Pallidus - physiology
globus pallidus interna
Humans
Influence
Male
Medical sciences
Mental depression
Middle Aged
Mood Disorders - etiology
Neurology
Parkinson Disease - therapy
Parkinson's disease
Physiological aspects
Short Report
Statistics
Studies
Substance abuse treatment
subthalamic nucleus
Subthalamic Nucleus - pathology
Subthalamic Nucleus - physiology
Thalamus
title Mood changes with deep brain stimulation of STN and GPi: results of a pilot study
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