The effect of interferon beta-1a on spasticity in primary progressive multiple sclerosis

To investigate this phenomenon further, we conducted a retrospective analysis of the spasticity studied in the recently published randomised controlled trial of interferon beta-1a in PPMS. 2 We randomised 50 subjects to receive weekly for two years an intramuscular injection of either interferon bet...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2004-03, Vol.75 (3), p.508-509
Main Authors: Leary, S M, Thompson, A J
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Care and treatment
Complications and side effects
Disease Progression
Double-Blind Method
Humans
Injections, Intramuscular
Interferon
Interferon beta
Interferon beta-1a
Interferon-beta - pharmacology
Letter
Multiple sclerosis
Multiple Sclerosis - complications
Muscle Spasticity - drug therapy
Muscle Spasticity - etiology
Placebos
Retrospective Studies
Treatment Outcome
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Description
Summary:To investigate this phenomenon further, we conducted a retrospective analysis of the spasticity studied in the recently published randomised controlled trial of interferon beta-1a in PPMS. 2 We randomised 50 subjects to receive weekly for two years an intramuscular injection of either interferon beta-1a 30 [micro]g (15 subjects); or interferon beta-1a 60 [micro]g (15 subjects); or placebo (20 subjects).
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2003.018598