A comparison of health utility measures for the evaluation of multiple sclerosis treatments

Objectives: To evaluate the practical application and psychometric properties of three health utility measures in a sample of MS patients with a broad range of neurological disability as measured by the Extended Disability Status Scale (EDSS). Methods: Patients randomly selected from two MS clinic r...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2005-01, Vol.76 (1), p.58-63
Main Authors: Fisk, J D, Brown, M G, Sketris, I S, Metz, L M, Murray, T J, Stadnyk, K J
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - therapeutic use
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Clinical trials
Cross-Sectional Studies
Disability Evaluation
EDSS
Extended Disability Status Scale
Female
Glatiramer Acetate
health related quality of life
Health Status Indicators
Health Utilities Index Mark III
health utility measures
HRQoL
HUI Mark III
Humans
Immunomodulators
Interferon
Interferon beta-1a
Interferon beta-1b
Interferon-beta - therapeutic use
Male
Medical Outcomes Study Short Form 36
Medical sciences
Middle Aged
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Peptides - therapeutic use
Pharmacology. Drug treatments
Psychometrics
QALY
quality adjusted life year
Quality of Life
Questionnaires
Reproducibility of Results
SF-36
Treatment Outcome
Citations: Items that cite this one
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Description
Summary:Objectives: To evaluate the practical application and psychometric properties of three health utility measures in a sample of MS patients with a broad range of neurological disability as measured by the Extended Disability Status Scale (EDSS). Methods: Patients randomly selected from two MS clinic registries were assessed using standard clinical methods and completed three generic measures of health utility (EQ-5D, HUI Mark III, SF-6D). The proportion of missing data, test/retest reliability, and construct validity of each health utility measure were examined. Results: The assessments were completed by 187 patients. Less than 10% of data were missing for the subscales of the SF-6D (
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2003.017897