Differentiation of Parkinson’s disease and atypical parkinsonian syndromes by transcranial ultrasound

Neuroimaging is known to complement clinical findings in the diagnostic work up of parkinsonian syndromes. Recently, transcranial ultrasound was reported to have a high diagnostic yield in differentiating idiopathic Parkinson’s disease (IPD) from atypical parkinsonian syndromes. This report summaris...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2005-03, Vol.76 (3), p.423-425
Main Authors: Behnke, S, Berg, D, Naumann, M, Becker, G
Format: Article
Language:English
Subjects:
Aged
atypical parkinsonian syndromes
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnosis, Differential
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
idiopathic Parkinson’s disease
IPD
Male
Medical sciences
Middle Aged
MSA-P
Multiple System Atrophy - diagnostic imaging
Nervous system (semeiology, syndromes)
neuroimaging
Neurology
Observer Variation
Parkinson Disease - diagnostic imaging
Parkinson's disease
Parkinsonian Disorders - diagnostic imaging
parkinsonian variant of multiple system atrophy
progressive supranuclear palsy
PSP
Sensitivity and Specificity
Short Report
Skull - diagnostic imaging
substantia nigra
TCS
transcranial sonography
transcranial ultrasound
Ultrasonography
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuroimaging is known to complement clinical findings in the diagnostic work up of parkinsonian syndromes. Recently, transcranial ultrasound was reported to have a high diagnostic yield in differentiating idiopathic Parkinson’s disease (IPD) from atypical parkinsonian syndromes. This report summarises the sonographic findings of 102 patients with IPD, 34 patients with multiple system atrophy, and 21 patients with progressive supranuclear palsy. Increased echogenicity of the substantia nigra is predictive for IPD whereas a low echogenic substantia nigra, particularly when combined with a hyperechogenic lentiform nucleus, strongly suggests an atypical Parkinsonian syndrome. The underlying causes for the differential echo pattern of the substantia nigra remain unknown.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2004.049221