Restless legs syndrome and low brain iron levels in patients with haemochromatosis

Regional brain iron levels of two patients with haemochromatosis and severe restless legs syndrome (RLS) were assessed using R2′ magnetic resonance imaging (MRI) sequences in both patients and in nine healthy controls. R2′ relaxation rates in the patients were decreased in the substantia nigra, red...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2005-07, Vol.76 (7), p.1009-1010
Main Authors: Haba-Rubio, J, Staner, L, Petiau, C, Erb, G, Schunck, T, Macher, J P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood-brain barrier
Brain
Brain - pathology
Brain Diseases - diagnosis
Brain Diseases - genetics
Caudate Nucleus - pathology
Fatigue
Female
Ferritins - metabolism
Globus Pallidus - pathology
Hemochromatosis - diagnosis
Hemochromatosis - genetics
Hemochromatosis Protein
Histocompatibility Antigens Class I - genetics
Humans
Image Processing, Computer-Assisted
Injuries of the nervous system and the skull. Diseases due to physical agents
Iron
Iron - metabolism
Magnetic Resonance Imaging
Male
Medical sciences
Membrane Proteins - genetics
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
NMR
Nuclear magnetic resonance
Patients
periodic limb movements in sleep
PLMS
Polysomnography
Putamen - pathology
Red Nucleus - pathology
Reference Values
Restless legs syndrome
Restless Legs Syndrome - diagnosis
Restless Legs Syndrome - genetics
RLS
Short Report
Sleep
Substantia Nigra - pathology
Traumas. Diseases due to physical agents
Citations: Items that cite this one
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Description
Summary:Regional brain iron levels of two patients with haemochromatosis and severe restless legs syndrome (RLS) were assessed using R2′ magnetic resonance imaging (MRI) sequences in both patients and in nine healthy controls. R2′ relaxation rates in the patients were decreased in the substantia nigra, red nucleus, and pallidum when compared with the controls. These results indicate that local brain iron deficiency may occur in patients with haemochromatosis and suggest a role for brain iron metabolism in the pathophysiology of RLS.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2003.030536