Anthracycline-induced cardiomyopathy

Anthracycline cardiomyopathy is less frequently encountered nowadays, due to the well-recognised dose limitations and cardiac monitoring protocols used by chemotherapy centres. However, it is a condition that will persist due to the sensitivity of some patients to these drugs and the necessity for l...

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Bibliographic Details
Published in:Postgraduate medical journal 1999-05, Vol.75 (883), p.265-268
Main Authors: Fisher, N G, Marshall, A J
Format: Article
Language:English
Subjects:
anthracycline
Antibiotics, Antineoplastic - adverse effects
Biological and medical sciences
Cardiomyopathies - chemically induced
Cardiomyopathies - drug therapy
Cardiomyopathies - prevention & control
Cardiomyopathy
Chemotherapy
Drug toxicity and drugs side effects treatment
Echocardiography
Epidemiology
Female
Free radicals
Heart attacks
Humans
Medical sciences
Middle Aged
Mortality
Pharmacology. Drug treatments
Review
Studies
Toxicity: cardiovascular system
Ventricular Dysfunction, Left - chemically induced
Ventricular Dysfunction, Left - drug therapy
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Summary:Anthracycline cardiomyopathy is less frequently encountered nowadays, due to the well-recognised dose limitations and cardiac monitoring protocols used by chemotherapy centres. However, it is a condition that will persist due to the sensitivity of some patients to these drugs and the necessity for large doses to be used for certain individuals. We have demonstrated the benefit of angiotensin-converting enzyme inhibitor therapy and would consider introducing these compounds at the earliest opportunity. The use of probucol and vitamins as antioxidants capable of preventing the onset of cardiomyopathy in humans appears to require further investigation but may significantly reduce the incidence of this condition in the future.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.75.883.265