Trends in diagnostic and therapeutic criteria in Graves' disease in the last 10 years

A questionnaire describing a typical clinical case of Graves' disease and 10 variations on it was mailed to 70 Spanish units of endocrinology with the aim of assessing the new diagnostic and therapeutic trends for hyperthyroidism caused by Graves' disease in Spain and to compare the result...

Full description

Saved in:
Bibliographic Details
Published in:Postgraduate medical journal 2000-06, Vol.76 (896), p.340-344
Main Authors: Escobar-Jiménez, F, Férnandez-Soto, M L, Luna-López, V, Quesada-Charneco, M, Glinoer, D
Format: Article
Language:English
Subjects:
Antibodies
Antithyroid Agents - therapeutic use
antithyroid drugs
Autoantibodies - blood
Biomarkers - blood
Endocrinology - trends
Graves disease
Graves Disease - diagnosis
Graves Disease - drug therapy
Humans
Hyperthyroidism
Iodide Peroxidase - immunology
Iodine
Iodine Radioisotopes - therapeutic use
Original
Polls & surveys
Questionnaires
radioiodine
Receptors, Thyrotropin - immunology
Recurrence
Scintigraphy
Spain
surgery
Surveys and Questionnaires
Thyroid Function Tests - trends
Thyroid gland
Thyrotropin - blood
Thyroxine - blood
Trends
Ultrasonic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3
cites cdi_FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3
container_end_page 344
container_issue 896
container_start_page 340
container_title Postgraduate medical journal
container_volume 76
creator Escobar-Jiménez, F
Férnandez-Soto, M L
Luna-López, V
Quesada-Charneco, M
Glinoer, D
description A questionnaire describing a typical clinical case of Graves' disease and 10 variations on it was mailed to 70 Spanish units of endocrinology with the aim of assessing the new diagnostic and therapeutic trends for hyperthyroidism caused by Graves' disease in Spain and to compare the results obtained from previous studies carried out in Europe and Spain 10 years previously.  Responses indicated that thyrotrophin (98%) and free thyroxine (88%) were the most used tests in the in vitro diagnosis of Graves' disease with a significant decrease in the use of total thyroxine, total triiodothyronine, and thyroglobulin in comparison with the surveys conducted 10 years previously in Europe and Spain. The presence of antibodies against the thyrotrophin receptor was the most frequently used immune marker in the diagnosis (78%) and the new use of antithyroperoxidase antibodies (36%) in diagnosis is noteworthy. Antithyroid drugs remain the treatment of choice (98%). Surgery was used mainly for large size goitres (33%) and radioiodine for recurrences after medical (61%) or surgical (80%) treatment.  In conclusion, the responses obtained from this questionnaire provide insight into current specialist diagnostic and therapeutic practices with respect to Graves' disease and which could be of value to non-specialist units of endocrinology.
doi_str_mv 10.1136/pmj.76.896.340
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1741609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71138269</sourcerecordid><originalsourceid>FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi1ERbeFK0cUCYmKQ4IdO_64VIIVtEXl49CuEBdr4sy2XrLJYicV_fd1lKoqXDhZ9jx-ZuyXkJeMFoxx-W633RRKFtrIggv6hCyYkCanqpJPyYJSXuaVUHyfHMS4oZRxJdgzss-oLgUVakEuLwJ2Tcx8lzUerro-Dt5l0DXZcI0BdjhOexf8gMHDhJ0EuMF4lPCIEHE6SmjWQhwyRrNbhBCfk701tBFf3K-H5PLTx4vlaX7-7eRs-f48r4WWQ84rVQNzrDLK6cowBVoIXbIGTIWGGYFMCZAOalCKaSrqtXaaKS54baBCfkiOZ-9urLfYOOyGAK3dBb-FcGt78PbvSuev7VV_Y5OXSWqS4M29IPS_R4yD3frosG2hw36MVqVP1qWcwNf_gJt-DF16XHKlkZJPVIkqZsqFPsaA64dRGLVTXjblZZW0KS-b8koXXj1-wCN8DigB-Qz4OOCfhzqEX1Yqrir7dbW0n398WP0sV9_tl8S_nfk6NfpP8ztUtqzv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781774145</pqid></control><display><type>article</type><title>Trends in diagnostic and therapeutic criteria in Graves' disease in the last 10 years</title><source>PubMed Central</source><creator>Escobar-Jiménez, F ; Férnandez-Soto, M L ; Luna-López, V ; Quesada-Charneco, M ; Glinoer, D</creator><creatorcontrib>Escobar-Jiménez, F ; Férnandez-Soto, M L ; Luna-López, V ; Quesada-Charneco, M ; Glinoer, D</creatorcontrib><description>A questionnaire describing a typical clinical case of Graves' disease and 10 variations on it was mailed to 70 Spanish units of endocrinology with the aim of assessing the new diagnostic and therapeutic trends for hyperthyroidism caused by Graves' disease in Spain and to compare the results obtained from previous studies carried out in Europe and Spain 10 years previously.  Responses indicated that thyrotrophin (98%) and free thyroxine (88%) were the most used tests in the in vitro diagnosis of Graves' disease with a significant decrease in the use of total thyroxine, total triiodothyronine, and thyroglobulin in comparison with the surveys conducted 10 years previously in Europe and Spain. The presence of antibodies against the thyrotrophin receptor was the most frequently used immune marker in the diagnosis (78%) and the new use of antithyroperoxidase antibodies (36%) in diagnosis is noteworthy. Antithyroid drugs remain the treatment of choice (98%). Surgery was used mainly for large size goitres (33%) and radioiodine for recurrences after medical (61%) or surgical (80%) treatment.  In conclusion, the responses obtained from this questionnaire provide insight into current specialist diagnostic and therapeutic practices with respect to Graves' disease and which could be of value to non-specialist units of endocrinology.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pmj.76.896.340</identifier><identifier>PMID: 10824047</identifier><language>eng</language><publisher>England: The Fellowship of Postgraduate Medicine</publisher><subject>Antibodies ; Antithyroid Agents - therapeutic use ; antithyroid drugs ; Autoantibodies - blood ; Biomarkers - blood ; Endocrinology - trends ; Graves disease ; Graves Disease - diagnosis ; Graves Disease - drug therapy ; Humans ; Hyperthyroidism ; Iodide Peroxidase - immunology ; Iodine ; Iodine Radioisotopes - therapeutic use ; Original ; Polls &amp; surveys ; Questionnaires ; radioiodine ; Receptors, Thyrotropin - immunology ; Recurrence ; Scintigraphy ; Spain ; surgery ; Surveys and Questionnaires ; Thyroid Function Tests - trends ; Thyroid gland ; Thyrotropin - blood ; Thyroxine - blood ; Trends ; Ultrasonic imaging</subject><ispartof>Postgraduate medical journal, 2000-06, Vol.76 (896), p.340-344</ispartof><rights>The Fellowship of Postgraduate Medicine</rights><rights>Copyright: 2000 The Fellowship of Postgraduate Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3</citedby><cites>FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741609/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741609/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10824047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Escobar-Jiménez, F</creatorcontrib><creatorcontrib>Férnandez-Soto, M L</creatorcontrib><creatorcontrib>Luna-López, V</creatorcontrib><creatorcontrib>Quesada-Charneco, M</creatorcontrib><creatorcontrib>Glinoer, D</creatorcontrib><title>Trends in diagnostic and therapeutic criteria in Graves' disease in the last 10 years</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>A questionnaire describing a typical clinical case of Graves' disease and 10 variations on it was mailed to 70 Spanish units of endocrinology with the aim of assessing the new diagnostic and therapeutic trends for hyperthyroidism caused by Graves' disease in Spain and to compare the results obtained from previous studies carried out in Europe and Spain 10 years previously.  Responses indicated that thyrotrophin (98%) and free thyroxine (88%) were the most used tests in the in vitro diagnosis of Graves' disease with a significant decrease in the use of total thyroxine, total triiodothyronine, and thyroglobulin in comparison with the surveys conducted 10 years previously in Europe and Spain. The presence of antibodies against the thyrotrophin receptor was the most frequently used immune marker in the diagnosis (78%) and the new use of antithyroperoxidase antibodies (36%) in diagnosis is noteworthy. Antithyroid drugs remain the treatment of choice (98%). Surgery was used mainly for large size goitres (33%) and radioiodine for recurrences after medical (61%) or surgical (80%) treatment.  In conclusion, the responses obtained from this questionnaire provide insight into current specialist diagnostic and therapeutic practices with respect to Graves' disease and which could be of value to non-specialist units of endocrinology.</description><subject>Antibodies</subject><subject>Antithyroid Agents - therapeutic use</subject><subject>antithyroid drugs</subject><subject>Autoantibodies - blood</subject><subject>Biomarkers - blood</subject><subject>Endocrinology - trends</subject><subject>Graves disease</subject><subject>Graves Disease - diagnosis</subject><subject>Graves Disease - drug therapy</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Iodide Peroxidase - immunology</subject><subject>Iodine</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Original</subject><subject>Polls &amp; surveys</subject><subject>Questionnaires</subject><subject>radioiodine</subject><subject>Receptors, Thyrotropin - immunology</subject><subject>Recurrence</subject><subject>Scintigraphy</subject><subject>Spain</subject><subject>surgery</subject><subject>Surveys and Questionnaires</subject><subject>Thyroid Function Tests - trends</subject><subject>Thyroid gland</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Trends</subject><subject>Ultrasonic imaging</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi1ERbeFK0cUCYmKQ4IdO_64VIIVtEXl49CuEBdr4sy2XrLJYicV_fd1lKoqXDhZ9jx-ZuyXkJeMFoxx-W633RRKFtrIggv6hCyYkCanqpJPyYJSXuaVUHyfHMS4oZRxJdgzss-oLgUVakEuLwJ2Tcx8lzUerro-Dt5l0DXZcI0BdjhOexf8gMHDhJ0EuMF4lPCIEHE6SmjWQhwyRrNbhBCfk701tBFf3K-H5PLTx4vlaX7-7eRs-f48r4WWQ84rVQNzrDLK6cowBVoIXbIGTIWGGYFMCZAOalCKaSrqtXaaKS54baBCfkiOZ-9urLfYOOyGAK3dBb-FcGt78PbvSuev7VV_Y5OXSWqS4M29IPS_R4yD3frosG2hw36MVqVP1qWcwNf_gJt-DF16XHKlkZJPVIkqZsqFPsaA64dRGLVTXjblZZW0KS-b8koXXj1-wCN8DigB-Qz4OOCfhzqEX1Yqrir7dbW0n398WP0sV9_tl8S_nfk6NfpP8ztUtqzv</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>Escobar-Jiménez, F</creator><creator>Férnandez-Soto, M L</creator><creator>Luna-López, V</creator><creator>Quesada-Charneco, M</creator><creator>Glinoer, D</creator><general>The Fellowship of Postgraduate Medicine</general><general>Oxford University Press</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200006</creationdate><title>Trends in diagnostic and therapeutic criteria in Graves' disease in the last 10 years</title><author>Escobar-Jiménez, F ; Férnandez-Soto, M L ; Luna-López, V ; Quesada-Charneco, M ; Glinoer, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibodies</topic><topic>Antithyroid Agents - therapeutic use</topic><topic>antithyroid drugs</topic><topic>Autoantibodies - blood</topic><topic>Biomarkers - blood</topic><topic>Endocrinology - trends</topic><topic>Graves disease</topic><topic>Graves Disease - diagnosis</topic><topic>Graves Disease - drug therapy</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Iodide Peroxidase - immunology</topic><topic>Iodine</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Original</topic><topic>Polls &amp; surveys</topic><topic>Questionnaires</topic><topic>radioiodine</topic><topic>Receptors, Thyrotropin - immunology</topic><topic>Recurrence</topic><topic>Scintigraphy</topic><topic>Spain</topic><topic>surgery</topic><topic>Surveys and Questionnaires</topic><topic>Thyroid Function Tests - trends</topic><topic>Thyroid gland</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Trends</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escobar-Jiménez, F</creatorcontrib><creatorcontrib>Férnandez-Soto, M L</creatorcontrib><creatorcontrib>Luna-López, V</creatorcontrib><creatorcontrib>Quesada-Charneco, M</creatorcontrib><creatorcontrib>Glinoer, D</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escobar-Jiménez, F</au><au>Férnandez-Soto, M L</au><au>Luna-López, V</au><au>Quesada-Charneco, M</au><au>Glinoer, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in diagnostic and therapeutic criteria in Graves' disease in the last 10 years</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>2000-06</date><risdate>2000</risdate><volume>76</volume><issue>896</issue><spage>340</spage><epage>344</epage><pages>340-344</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>A questionnaire describing a typical clinical case of Graves' disease and 10 variations on it was mailed to 70 Spanish units of endocrinology with the aim of assessing the new diagnostic and therapeutic trends for hyperthyroidism caused by Graves' disease in Spain and to compare the results obtained from previous studies carried out in Europe and Spain 10 years previously.  Responses indicated that thyrotrophin (98%) and free thyroxine (88%) were the most used tests in the in vitro diagnosis of Graves' disease with a significant decrease in the use of total thyroxine, total triiodothyronine, and thyroglobulin in comparison with the surveys conducted 10 years previously in Europe and Spain. The presence of antibodies against the thyrotrophin receptor was the most frequently used immune marker in the diagnosis (78%) and the new use of antithyroperoxidase antibodies (36%) in diagnosis is noteworthy. Antithyroid drugs remain the treatment of choice (98%). Surgery was used mainly for large size goitres (33%) and radioiodine for recurrences after medical (61%) or surgical (80%) treatment.  In conclusion, the responses obtained from this questionnaire provide insight into current specialist diagnostic and therapeutic practices with respect to Graves' disease and which could be of value to non-specialist units of endocrinology.</abstract><cop>England</cop><pub>The Fellowship of Postgraduate Medicine</pub><pmid>10824047</pmid><doi>10.1136/pmj.76.896.340</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0032-5473
ispartof Postgraduate medical journal, 2000-06, Vol.76 (896), p.340-344
issn 0032-5473
1469-0756
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1741609
source PubMed Central
subjects Antibodies
Antithyroid Agents - therapeutic use
antithyroid drugs
Autoantibodies - blood
Biomarkers - blood
Endocrinology - trends
Graves disease
Graves Disease - diagnosis
Graves Disease - drug therapy
Humans
Hyperthyroidism
Iodide Peroxidase - immunology
Iodine
Iodine Radioisotopes - therapeutic use
Original
Polls & surveys
Questionnaires
radioiodine
Receptors, Thyrotropin - immunology
Recurrence
Scintigraphy
Spain
surgery
Surveys and Questionnaires
Thyroid Function Tests - trends
Thyroid gland
Thyrotropin - blood
Thyroxine - blood
Trends
Ultrasonic imaging
title Trends in diagnostic and therapeutic criteria in Graves' disease in the last 10 years
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A45%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trends%20in%20diagnostic%20and%20therapeutic%20criteria%20in%20Graves'%20disease%20in%20the%20last%2010%20years&rft.jtitle=Postgraduate%20medical%20journal&rft.au=Escobar-Jim%C3%A9nez,%20F&rft.date=2000-06&rft.volume=76&rft.issue=896&rft.spage=340&rft.epage=344&rft.pages=340-344&rft.issn=0032-5473&rft.eissn=1469-0756&rft_id=info:doi/10.1136/pmj.76.896.340&rft_dat=%3Cproquest_pubme%3E71138269%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b486t-357ba1c1597c85917a844821da95e9194e174a6caba771804bf8c817343b9a5e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1781774145&rft_id=info:pmid/10824047&rfr_iscdi=true