Heart and mind: (2) psychotropic and cardiovascular therapeutics

There is a plausible biological basis for the association between psychiatric morbidity and cardiovascular disease. Anxiety, panic disorder, and depression are common in patients with coronary heart disease and hypertension. Despite this evidence there is poor recognition of anxiety disorders and de...

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Bibliographic Details
Published in:Postgraduate Medical Journal 2005-01, Vol.81 (951), p.33-40
Main Authors: Shah, S U, Iqbal, Z, White, A, White, S
Format: Article
Language:English
Subjects:
Antidepressants
anxiety
Biological and medical sciences
Cardiac arrhythmia
Cardiovascular Agents - adverse effects
Cardiovascular Agents - pharmacology
cardiovascular disease
Cardiovascular Diseases - complications
Cardiovascular Diseases - drug therapy
Committee on Safety of Medicines
CSM
depression
drug interaction
Drug Interactions
Electrocardiography
GABA
gamma amino butyric acid
General aspects
Heart attacks
Humans
Medical sciences
Mental Disorders - complications
Mental Disorders - drug therapy
pharmacotherapy
psychiatric disease
Psychotropic drugs
Psychotropic Drugs - pharmacology
Review
selective serotonin reuptake inhibitor
SSRI
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Summary:There is a plausible biological basis for the association between psychiatric morbidity and cardiovascular disease. Anxiety, panic disorder, and depression are common in patients with coronary heart disease and hypertension. Despite this evidence there is poor recognition of anxiety disorders and depression in primary care and hospital medical practice. Concern also surrounds the use of psychotropic drugs in patients with cardiovascular disease. In the first of the two articles on this subject, we highlighted the current evidence regarding the association between cardiovascular and psychotropic conditions. In this second article, we discuss the interaction of the drugs used in the management of these two varied but commonly coexistent group of diseases as well as their relative effects on either system. Finally, we summarise the data regarding the safe use of these medications based on the recommendations from the currently available evidence.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.2003.015230