Increasing relative prevalence of HSV-2 infection among men with genital ulcers from a mining community in South Africa

Objectives: To determine the aetiology of genital ulcer disease (GUD) and its association with HIV infection in the mining community of Carletonville, South Africa, from two cross sectional surveys of consecutive men presenting with genital lesions during October 1993 to January 1994 and July to Nov...

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Bibliographic Details
Published in:Sexually transmitted infections 2003-06, Vol.79 (3), p.202-207
Main Authors: Lai, W, Chen, C Y, Morse, S A, Htun, Ye, Fehler, H G, Liu, H, Ballard, R C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Causes of
Chancroid - epidemiology
Cross-Sectional Studies
Disease control
DNA polymerase
Haemophilus ducreyi
Herpes genitalis
Herpes Genitalis - epidemiology
Herpes Genitalis - virology
Herpes simplex virus
Herpes viruses
Herpesvirus 2, Human - isolation & purification
Heterosexuality
HIV
HIV infection
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Laboratories
Male
Medical sciences
Middle Aged
Mining
Original
Physiological aspects
Polymerase Chain Reaction - methods
Prevalence
Real time
Sexually transmitted diseases
South Africa - epidemiology
STD
Syphilis
Syphilis - epidemiology
Treponema pallidum - isolation & purification
Tropical medicine
Ulcer - epidemiology
Ulcer - virology
Ulcers
Viral diseases
Viral diseases of the genital and urinary system
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Summary:Objectives: To determine the aetiology of genital ulcer disease (GUD) and its association with HIV infection in the mining community of Carletonville, South Africa, from two cross sectional surveys of consecutive men presenting with genital lesions during October 1993 to January 1994 and July to November 1998. Methods: A multiplex polymerase chain reaction (M-PCR) assay combined with amplicon detection was used to identify DNA specific sequences of Treponema pallidum, herpes simplex virus (HSV), and Haemophilus ducreyi. A real time PCR assay was used to differentiate between HSV-1 and HSV-2. Results: M-PCR detected T pallidum, HSV, and H ducreyi in 10.3%, 17.2%, and 69.4% of 232 GUD patients during 1993–4 and in 12.4%, 36.0%, and 50.5% of 186 GUD patients in 1998. The proportion of patients with more than one agent increased significantly from 7.3% (17/232) in 1993–4 to 16.7% (31/186) in 1998 (p
ISSN:1368-4973
1472-3263
DOI:10.1136/sti.79.3.202