Epidemiology of recurrent genital herpes simplex virus types 1 and 2

Objectives: To describe the epidemiology of type specific recurrent genital herpes, and to compare the duration of recurrent genital lesions caused by herpes simplex virus (HSV) types 1 and 2. Methods: Participants were enrolled at clinics across the United States. Adults suspected of having active...

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Bibliographic Details
Published in:Sexually transmitted infections 2003-12, Vol.79 (6), p.456-459
Main Authors: Solomon, L, Cannon, M J, Reyes, M, Graber, J M, Wetherall, N T, Reeves, W C
Format: Article
Language:English
Subjects:
Adult
African Americans
Aged
Biological and medical sciences
Cross-Sectional Studies
Diseases
Epidemiology
Ethnicity
Female
Fundamental and applied biological sciences. Psychology
General aspects
genital herpes
Gynecology. Andrology. Obstetrics
Herpes genitalis
Herpes Genitalis - epidemiology
Herpes Genitalis - virology
herpes simplex virus
Herpes viruses
Herpesvirus 1, Human
Herpesvirus 2, Human
Human infectious diseases. Experimental studies and models
Humans
Infectious diseases
Investigations
Male
Medical sciences
Microbiology
Middle Aged
Prevalence
Prognosis
Proportional Hazards Models
Recurrence
Relapse
Risk factors
Sex Distribution
Sexually transmitted diseases
Short Report
STD
United States - epidemiology
Variables
White people
Womens health
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Summary:Objectives: To describe the epidemiology of type specific recurrent genital herpes, and to compare the duration of recurrent genital lesions caused by herpes simplex virus (HSV) types 1 and 2. Methods: Participants were enrolled at clinics across the United States. Adults suspected of having active genital herpes were eligible. Lesions were cultured for HSV and typed. Data from 940 participants with recurrent culture positive HSV lesions were analysed. Pearson’s χ2 and Fisher’s exact tests, multivariate logistic regression models, and a stratified Cox proportional hazards model were used to compare epidemiological characteristics and lesion duration of HSV-1 and HSV-2. Results: HSV-1 was present in 4.2% of the recurrent HSV culture positive lesions. HSV-1 was most prevalent among whites (6.5%) and individuals with 0–2 recurrences in the previous year (9.1%) and, among men, in those with rectal/perirectal lesions (13.2%). Longer lesion duration was not significantly associated with virus type (hazard ratio (HR) 0.95, 95% confidence interval (CI) 0.65 to 1.38, p = 0.79), but was associated with male sex (HR 0.85, 95% CI 0.74 to 0.99, p = 0.04), and HIV seropositivity (HR 0.62, 95% CI 0.48 to 0.81, p
ISSN:1368-4973
1472-3263
DOI:10.1136/sti.79.6.456