Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations

Exacerbations represent an important feature of the clinical manifestation and natural history of chronic obstructive pulmonary disease (COPD). Nuclear localisation of p65 is a signal of nuclear factor-kappaB (NF-kappaB) activation. A study was undertaken to evaluate whether NF-kappaB activation is...

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Bibliographic Details
Published in:Thorax 2003-04, Vol.58 (4), p.348-351
Main Authors: CARAMORI, G, ROMAGNOLI, M, FABBRI, L. M, PAPI, A, CASOLARI, P, BELLETTATO, C, CASONI, G, BOSCHETTO, P, CHUNG, K. Fan, BARNES, P. J, ADCOCK, I. M, CIACCIA, A
Format: Article
Language:English
Subjects:
Aged
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Biological and medical sciences
Calcium-Binding Proteins
Care and treatment
Case studies
Cell Nucleus - chemistry
Chronic obstructive pulmonary disease, asthma
Female
Humans
Immunocytochemistry
Immunohistochemistry
Lung diseases, Obstructive
Macrophages - pathology
Male
Medical sciences
Membrane Glycoproteins - metabolism
Nerve Tissue Proteins - metabolism
Neutrophils - metabolism
NF-kappa B - metabolism
Pneumology
Pulmonary Disease, Chronic Obstructive - metabolism
Pulmonary Disease, Chronic Obstructive - pathology
Short Paper
Sputum - cytology
Synaptotagmin I
Synaptotagmins
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Summary:Exacerbations represent an important feature of the clinical manifestation and natural history of chronic obstructive pulmonary disease (COPD). Nuclear localisation of p65 is a signal of nuclear factor-kappaB (NF-kappaB) activation. A study was undertaken to evaluate whether NF-kappaB activation is modified in sputum cells during COPD exacerbations. Total and nuclear p65 immunoreactivity was measured by immunocytochemistry in the sputum cells of 11 smokers with moderate COPD during an exacerbation and after 6-8 weeks of clinical stability. Total sputum cell count was significantly increased during exacerbations from a median (IQR) of 880 (510-1865) to 1914.5 (1065-3205) x 10(3)/ml (p
ISSN:0040-6376
1468-3296
DOI:10.1136/thorax.58.4.348