Pulmonary hypertension in patients with COPD: NO treatment?

[...]the therapeutic efficacy of inhaled NO may not rise dramatically with increased doses as the more NO given, the faster it is oxidised. 9 In fact, higher doses of NO result in a relatively greater proportion of toxic products with little incremental yield of intact NO. [...]the rapid inactivatio...

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Bibliographic Details
Published in:Thorax 2003-04, Vol.58 (4), p.283-284
Main Authors: Pepke-Zaba, J, Morrell, N W
Format: Article
Language:English
Subjects:
Administration, Inhalation
Care and treatment
Chronic obstructive pulmonary disease
Humans
Hypertension, Pulmonary - etiology
Long term
Lungs
Mortality
Nitric oxide
Nitric Oxide - physiology
Nitric Oxide - therapeutic use
Nitrogen dioxide
Oxyhemoglobins - metabolism
Physiology
Pulmonary arteries
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary hypertension
Quality of life
Vasodilation - drug effects
Vasodilator Agents - therapeutic use
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Description
Summary:[...]the therapeutic efficacy of inhaled NO may not rise dramatically with increased doses as the more NO given, the faster it is oxidised. 9 In fact, higher doses of NO result in a relatively greater proportion of toxic products with little incremental yield of intact NO. [...]the rapid inactivation of inhaled NO in an oxygen rich environment is what makes NO a selective pulmonary vasodilator.
ISSN:0040-6376
1468-3296
DOI:10.1136/thorax.58.4.283