Effect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPD

Background: Some patients with irreversible chronic obstructive pulmonary disease (COPD) experience subjective benefit from long acting bronchodilators without change in forced expiratory volume in 1 second (FEV1). Dynamic hyperinflation is an important determinant of exercise induced dyspnoea in CO...

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Bibliographic Details
Published in:Thorax 2004-06, Vol.59 (6), p.471-476
Main Authors: Man, W D C, Mustfa, N, Nikoletou, D, Kaul, S, Hart, N, Rafferty, G F, Donaldson, N, Polkey, M I, Moxham, J
Format: Article
Language:English
Subjects:
Aged
Albuterol - analogs & derivatives
Albuterol - therapeutic use
arterial oxygen and carbon dioxide tensions
Biological and medical sciences
Bronchodilator Agents - therapeutic use
carbon monoxide transfer factor
Chronic obstructive pulmonary disease
diaphragmatic pressure
Double-Blind Method
dynamic hyperinflation
EELV
EILV
end expiratory lung volume
end inspiratory lung volume FEV1
Exercise - physiology
Fatigue
Female
Fitness equipment
Forced Expiratory Volume - physiology
forced expiratory volume in 1 second
gastric pressure
Humans
Hyperinflation
incremental shuttle walk
inspiratory capacity
inspiratory reserve volume
intrinsic positive end expiratory pressure
IRV
ISW
Male
maximum inspiratory pressure
Medical sciences
oesophageal pressure
Paco2
Pao2
Pdi
peak oxygen consumption
PEEPi
Pga
Physiology
Pimax
Pneumology
Poes
pressure-time product
PTP
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary Disease, Chronic Obstructive - physiopathology
residual volume
Respiratory Muscles
Respiratory Muscles - drug effects
Respiratory therapy
salmeterol
Salmeterol Xinafoate
TLC
Tlco
total lung capacity
vital capacity
Vital Capacity - physiology
Vo2peak
Walking
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Summary:Background: Some patients with irreversible chronic obstructive pulmonary disease (COPD) experience subjective benefit from long acting bronchodilators without change in forced expiratory volume in 1 second (FEV1). Dynamic hyperinflation is an important determinant of exercise induced dyspnoea in COPD. We hypothesised that long acting bronchodilators improve symptoms by reducing dynamic hyperinflation and work of breathing, as measured by respiratory muscle pressure-time products. Methods: Sixteen patients with “irreversible” COPD (
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.2003.019620