Differential expression of VASP in normal lung tissue and lung adenocarcinomas

Background: Vasodilator stimulated phosphoprotein (VASP) is associated with focal adhesions and is thought to have an important role in actin filament assembly and cell motility. We hypothesise that an increase in the expression of VASP is involved in the progression and invasion of lung adenocarcin...

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Bibliographic Details
Published in:Thorax 2005-07, Vol.60 (7), p.576-581
Main Authors: Dertsiz, L, Ozbilim, G, Kayisli, Y, Gokhan, G A, Demircan, A, Kayisli, U A
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Aged
Angiogenesis
Biological and medical sciences
Cell adhesion & migration
Cell Adhesion Molecules - metabolism
Cell growth
Disease Progression
Female
Humans
Immunohistochemistry
Localization
Lung - metabolism
Lung Cancer
Lung Neoplasms - metabolism
Male
Medical sciences
Microfilament Proteins
Middle Aged
Motility
Phosphoproteins - metabolism
Pneumology
Proteins
Statistical analysis
Studies
Tumorigenesis
Tumors
Tumors of the respiratory system and mediastinum
Variance analysis
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Summary:Background: Vasodilator stimulated phosphoprotein (VASP) is associated with focal adhesions and is thought to have an important role in actin filament assembly and cell motility. We hypothesise that an increase in the expression of VASP is involved in the progression and invasion of lung adenocarcinomas in parallel to tumour progression. A study was undertaken to analyse VASP expression in normal lung tissue and lung adenocarcinomas. Methods: Human lung tissues with adenocarcinomas (n = 26) were used. Normal lung tissue specimens (n = 14) were taken from areas a standard distance (3 cm) from resected adenocarcinomas of patients who underwent surgical lung resection. Adenocarcinomas were classified according to pathological staging and histopathological grades. Tissues were stained for VASP using immunohistochemistry. Results: Normal lung pneumocytes showed no VASP expression while alveolar macrophages had the strongest immunoreactivity for VASP. Bronchial epithelium (surface epithelium, goblet cells) and bronchial gland cells had a very weak immunoreactivity for VASP. Adenocarcinomas had significantly greater VASP expression than normal epithelium (p
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.2004.037622