MBGD: a platform for microbial comparative genomics based on the automated construction of orthologous groups

The microbial genome database for comparative analysis (MBGD) is a comprehensive platform for microbial comparative genomics. The central function of MBGD is to create orthologous groups among multiple genomes from precomputed all-against-all similarity relationships using the DomClust algorithm. Th...

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Bibliographic Details
Published in:Nucleic acids research 2007-01, Vol.35 (suppl-1), p.D343-D346
Main Author: Uchiyama, Ikuo
Format: Article
Language:English
Subjects:
Algorithms
Databases, Nucleic Acid
Genome, Archaeal
Genome, Bacterial
Genomics
Internet
Sequence Alignment
User-Computer Interface
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Summary:The microbial genome database for comparative analysis (MBGD) is a comprehensive platform for microbial comparative genomics. The central function of MBGD is to create orthologous groups among multiple genomes from precomputed all-against-all similarity relationships using the DomClust algorithm. The database now contains >300 published genomes and the number continues to grow. For researchers who are interested in ongoing genome projects, we have now started a new service called 'My MBGD,' which allows users to add their own genome sequences to MBGD for the purpose of identifying orthologs among both the new and the existing genomes. Furthermore, in order to make available the rapidly accumulating information on closely related genome sequences, we enhanced the interface for pairwise genome comparisons using the CGAT interface, which allows users to see nucleotide sequence alignments of non-coding as well as coding regions. MBGD is available at http://mbgd.genome.ad.jp/.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkl978