Autoantibodies predicting the outcome of rheumatoid arthritis: evaluation in two subsets of patients according to severity of radiographic damage

OBJECTIVE Autoantibodies such as rheumatoid factor (RF), antikeratin antibodies (AKA), antiperinuclear factor (APF), and anti-RA 33 antibodies are considered of value for the diagnosis of RA. The purpose of this study was to evaluate these autoantibodies as predictors of severe radiographic damage i...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the rheumatic diseases 1997-11, Vol.56 (11), p.682-685
Main Authors: Meyer, O, Combe, B, Elias, A, Benali, K, Clot, J, Sany, J, Eliaou, J F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Antinuclear - blood
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - immunology
Arthrography
autoantibodies
Autoantibodies - blood
Biological and medical sciences
Biomarkers - blood
Blood Sedimentation
C-Reactive Protein - analysis
Concise Reports
Diseases of the osteoarticular system
Evaluation Studies as Topic
Female
Foot - diagnostic imaging
Hand - diagnostic imaging
HLA-DR Antigens - analysis
HLA-DRB1 Chains
Humans
Immunoglobulins
Inflammatory joint diseases
Keratins - immunology
Laboratories
Male
Medical sciences
Middle Aged
Odds Ratio
Prognosis
prognostic factors
Proteins
Rheumatoid arthritis
Rheumatoid Factor - blood
Studies
Variables
Wrist Joint - diagnostic imaging
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE Autoantibodies such as rheumatoid factor (RF), antikeratin antibodies (AKA), antiperinuclear factor (APF), and anti-RA 33 antibodies are considered of value for the diagnosis of RA. The purpose of this study was to evaluate these autoantibodies as predictors of severe radiographic damage in rheumatoid arthritis (RA). PATIENTS AND METHODS Eighty six patients with RA (70 women, 16 men) fulfilling 1987 ACR criteria were selected from a cohort of 469 patients followed up since the first year of RA onset because they could be divided in two groups according to the severity of the radiographic damage. These 86 patients had a mean (SD) disease duration of eight (four) years: 43 patients had severe radiographic damage (Larsen score ⩾2) and 43 had limited radiographic damage (Larsen score < 2). The two groups were matched by disease duration and sex. The following autoantibodies were looked for: RF, ANA, AKA, APF, and anti-RA 33 antibodies. In addition, HLA class II DR β alleles and standard inflammatory parameters (erythrocyte sedimentation rate, C reactive protein) were determined. RESULTS Patients with severe radiographic damage differed from those with limited radiographic damage in that they had higher RF (p=0.01), APF (p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.56.11.682