Inflammatory arthritis in children with osteochondrodysplasias

• Published in: Annals of the rheumatic diseases 2000-11, Vol.59 (11), p.864-869
• Main Authors: Scuccimarri, Rosie, Azouz, E Michel, Duffy, Karen N Watanabe, Fassier, François, Duffy, Ciarán M
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antirheumatic Agents - therapeutic use; Arthritis; Arthritis, Juvenile - diagnosis; Arthritis, Juvenile - drug therapy; Arthritis, Juvenile - etiology; Biological and medical sciences; Cartilage; Child; Complications and side effects; Contrast Media; degenerative arthritis; Development and progression; Disease; Diseases of the osteoarticular system; Dysplasia; Extended Report; Female; Follow-Up Studies; Humans; juvenile arthritis; Magnetic Resonance Imaging; Male; Malformations and congenital and or hereditary diseases involving bones. Joint deformations; Medical sciences; Methotrexate - therapeutic use; Osteoarthritis - diagnosis; Osteoarthritis - drug therapy; Osteoarthritis - etiology; osteochondrodysplasias; Osteochondrodysplasias - complications; Osteochondrodysplasias - diagnosis; Patients; Physical therapy; Rheumatoid arthritis; spondyloepiphysial dysplasia; Treatment Outcome
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/ard.59.11.864

Osteochondrodysplasias are a heterogeneous group of genetic skeletal dysplasias. Patients with these diseases commonly develop an early degenerative arthritis or osteoarthritis. Occasional observations of inflammatory arthritis have been made in this population but such observations are based on clinical grounds alone without confirmatory imaging studies. Four patients followed up in a paediatric rheumatology clinic with three different skeletal dysplasias, who had both clinical and radiological evidence of an inflammatory arthritis and coexistent degenerative arthritis, are described.