Serum skeletal troponin I in inflammatory muscle disease: relation to creatine kinase, CKMB and cardiac troponin I

Diagnoses were established according to the criteria of Bohan and Peter 16 from clinical features of proximal muscle weakness with or without rash, serum total CK, EMG, muscle histology and in addition muscle magnetic resonance imaging. 19 20 Our series concurs with others who also report a raised C...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2000-09, Vol.59 (9), p.750-750
Main Authors: KIELY, P D W, BRUCKNER, F E, NISBET, J A, DAGHIR, A
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Creatine Kinase - blood
Cross-Sectional Studies
Dermatomyositis
Dermatomyositis - blood
Diagnosis
Disease
Female
Follow-Up Studies
Humans
Isoenzymes
Letters
Male
Middle Aged
Patients
Polymyositis
Polymyositis - blood
Troponin I - blood
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Summary:Diagnoses were established according to the criteria of Bohan and Peter 16 from clinical features of proximal muscle weakness with or without rash, serum total CK, EMG, muscle histology and in addition muscle magnetic resonance imaging. 19 20 Our series concurs with others who also report a raised CKMB/total CK ratio in patients with inflammatory muscle disease. 8 9 12 However, although a ratio >3% is usually interpreted as indicative of myocardial disease in adults, in inflammatory muscle disease this is more likely to reflect striated muscle damage alone. 6 10 11 In this situation the cTnI is of particular use in distinguishing between a striated and myocardial origin of a raised CKMB/total CK ratio as cTnI is expressed only in cardiac muscle. 15 In our cross sectional study the CKMB correlated with sTnI but not with cTnI, suggesting striated muscle was the source of the CKMB.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.59.9.750