Investigation of chromosome 2q in osteoarthritis of the hand: no significant linkage in a Tasmanian population

Background: Previous studies have suggested a strong genetic component to osteoarthritis (OA), especially that of the hand, and three linkage studies have suggested the existence of susceptibility loci in disparate regions of chromosome 2q. Objective: To examine for linkage to 2q in a Tasmanian popu...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2002-12, Vol.61 (12), p.1081-1084
Main Authors: Stankovich, J, Sale, M M, Cooley, H M, Bahlo, M, Reilly, A, Dickinson, J L, Jones, G
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Arthritis
Biological and medical sciences
centimorgans
Chromosomes
Chromosomes, Human, Pair 2 - genetics
CMC
DIP
Disease Susceptibility
Diseases of the osteoarticular system
distal interphalangeal
Extended Report
Family
Female
Finger Joint - diagnostic imaging
first carpometacarpal
Genetic aspects
Genetic Linkage - genetics
Genomes
Hand - diagnostic imaging
Hands
Humans
linkage analysis
Lod Score
Male
Medical sciences
Middle Aged
MLS
multipoint LOD score
non-parametric linkage
NPL
Older parents
Osteoarthritis
Osteoarthritis - genetics
Phenotype
Radiography
Tasmania
Women
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Summary:Background: Previous studies have suggested a strong genetic component to osteoarthritis (OA), especially that of the hand, and three linkage studies have suggested the existence of susceptibility loci in disparate regions of chromosome 2q. Objective: To examine for linkage to 2q in a Tasmanian population of women and men with familial hand OA. Methods: Hand OA (distal interphalangeal, carpometacarpal, and Heberden's nodes) was assessed by a combination of hand photographs and radiographs. A non-parametric linkage (NPL) analysis was performed on chromosome 2q of 69 members in 22 families with severe distal interphalangeal joint OA using Genehunter. A quantitative trait linkage analysis of a larger group of 456 members in 68 families was also performed using SOLAR. Results: The maximum non-parametric linkage score was 1.05 (p=0.15) at marker IL1R1, close to the centromere. All components of hand OA scores had significant heritability in this dataset (28%–35%, all p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.61.12.1081