The role of HLA genes in familial spondyloarthropathy: a comprehensive study of 70 multiplex families

Objectives: To investigate whether HLA alleles, other than HLA-B27, influence predisposition to spondyloarthropathy (SpA) in multiplex families. Methods: Seventy French families with at least two affected SpA members were recruited. Patients, and their first degree relatives were typed for HLA-A, B,...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2002-03, Vol.61 (3), p.201-206
Main Authors: Said-Nahal, R, Miceli-Richard, C, Gautreau, C, Tamouza, R, Borot, N, Porcher, R, Charron, D, Dougados, M, Breban, M
Format: Article
Language:English
Subjects:
Adult
Alleles
ankylosing spondylitis
Arthritis
Binomial Distribution
Biological and medical sciences
Chi-Square Distribution
confidence interval
Confidence Intervals
Disease
Diseases of the osteoarticular system
Extended Report
Female
France
Genetic aspects
Haplotypes
Health aspects
Histocompatibility antigens
HLA
HLA Antigens - genetics
HLA histocompatibility antigens
HLA-A Antigens - genetics
HLA-B27 Antigen - genetics
HLA-C Antigens - genetics
HLA-DR4 Antigen - genetics
Humans
Hypotheses
IBD
Inflammatory bowel disease
Inflammatory joint diseases
Linkage Disequilibrium
major histocompatibility complex
Male
Medical sciences
Methods
MHC
Middle Aged
Odds Ratio
Pedigree
Polymerase chain reaction
PsA
psoriatic arthritis
relative risk
rheumatoid arthritis
Siblings
SpA
Spondylarthropathies - genetics
Spondyloarthropathies
spondyloarthropathy
Studies
TDT
transmission disequilibrium test
undifferentiated spondyloarthropathy
uSpA
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Summary:Objectives: To investigate whether HLA alleles, other than HLA-B27, influence predisposition to spondyloarthropathy (SpA) in multiplex families. Methods: Seventy French families with at least two affected SpA members were recruited. Patients, and their first degree relatives were typed for HLA-A, B, C, and DR, and extended HLA haplotypes were determined. The distribution of HLA-A, C, and DR alleles carried on HLA-B27+ haplotypes in SpA families was compared with the distribution of these alleles among HLA-B27+ haplotypes in the French general population. Contribution to SpA susceptibility of HLA-A, B, C, and DR alleles, other than HLA-B27, was tested by transmission disequilibrium test. The contribution of HLA alleles to specific presentation features of SpA was examined. Results: Frequencies of HLA-A, C, and DR alleles carried on HLA-B27+ haplotypes from SpA families were comparable with those seen in the French population, except for DR13 which was overrepresented among patients (pcorr
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.61.3.201