A role for leptin in rheumatic diseases?

Leptin is a peptide hormone that has an important role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. [...]leptin exhibits a variety of other effects, including the regulation of endocrine function, reproduction, and immunity. 1, 2 Consistently, leptin...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2003-10, Vol.62 (10), p.913-915
Main Authors: Palmer, G, Gabay, C
Format: Article
Language:English
Subjects:
Animals
Antigens
Arthritis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - immunology
Autoimmunity - physiology
B-Lymphocytes - metabolism
Biological and medical sciences
Body mass index
Cytokines
Cytokines - immunology
Defects
Diabetes
Disease
Diseases of the osteoarticular system
Humans
Immune system
Inflammation
Inflammatory joint diseases
Leader
leptin
Leptin - physiology
Leptin - therapeutic use
Lymphocytes
Medical sciences
Models, Animal
Plasma
Receptors, Cell Surface - metabolism
Receptors, Leptin
Rheumatic diseases
rheumatoid arthritis
Rodents
Studies
Th1 Cells - immunology
Th1 Cells - metabolism
Th1/Th2 responses
Tumor necrosis factor-TNF
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Summary:Leptin is a peptide hormone that has an important role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. [...]leptin exhibits a variety of other effects, including the regulation of endocrine function, reproduction, and immunity. 1, 2 Consistently, leptin deficient (ob/ob) mice and leptin receptor deficient (db/db) mice are not only severely obese but also display hormonal imbalances, abnormalities in thermoregulation, infertility, and evidence of immune and haematopoietic defects. Despite the presence of methodological problems in their study, this point is of interest because experimental models suggest that leptin may influence the disease process in two opposing ways, either by enhancing the expression of Th1 cytokines or by limiting the inflammatory responses. [...]longitudinal studies including patients with early RA are still needed to clarify the potential influence of leptin on disease outcome, and particularly the progression of joint damage.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.62.10.913