Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene

Background: There is an association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and methotrexate related toxicity. Objective: To examine the relations between the recently described A1298C polymorphism of the MTHFR gene, plasma homocysteine, methotrexate toxici...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2004-10, Vol.63 (10), p.1227-1231
Main Authors: Berkun, Y, Levartovsky, D, Rubinow, A, Orbach, H, Aamar, S, Grenader, T, Abou Atta, I, Mevorach, D, Friedman, G, Ben-Yehuda, A
Format: Article
Language:English
Subjects:
Acids
Adult
Aged
Alleles
Antirheumatic Agents - adverse effects
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Biological and medical sciences
Cross-Sectional Studies
Dihydrofolate reductase
Disease
disease modifying antirheumatic drug
Diseases of the osteoarticular system
DMARD
Drug dosages
Enzymes
EULAR
European League Against Rheumatism
Extended Report
Female
Folic Acid - blood
Genotype
Genotype & phenotype
Health risk assessment
Homocysteine
Homocysteine - blood
Humans
Immunoassay
Inflammatory joint diseases
Male
Medical sciences
Metabolism
methotrexate
Methotrexate - adverse effects
methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
MTHFR
Mutation
Patients
Plasma
Polymorphism, Genetic
Rheumatoid arthritis
Rheumatology
Studies
Vitamin B
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Summary:Background: There is an association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and methotrexate related toxicity. Objective: To examine the relations between the recently described A1298C polymorphism of the MTHFR gene, plasma homocysteine, methotrexate toxicity, and disease activity in patients with rheumatoid arthritis. Design: A cross sectional study on 93 methotrexate treated patients with rheumatoid arthritis, comprising a clinical interview and physical examination to determine disease activity and methotrexate related adverse reactions. Genotype analysis of the MTHFR gene was carried out and fasting plasma homocysteine and serum folate concentrations were measured. The data were analysed using univariate analysis. Allele and genotype distributions were compared with those of a healthy control group. Results: The frequency of the 1298CC genotype (24.7%) in the rheumatoid study group was greater than expected in the general population (12.8%, p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2003.016337