Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism

Objectives: To investigate abnormalities of the hypothalamic-pituitary-gonadal (HPG) axis and cortisol concentrations in young women with primary fibromyalgia (FM); and to determine whether depression, fatigue, and sleep disturbance affect these hormones. Methods: Follicle stimulating hormone (FSH),...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2004-11, Vol.63 (11), p.1504-1506
Main Authors: Gur, A, Cevik, R, Sarac, A J, Colpan, L, Em, S
Format: Article
Language:English
Subjects:
ACR
Adult
American College of Rheumatology
Analysis of Variance
BDI
Beck Depression Inventory
Biological and medical sciences
Case-Control Studies
Chronic fatigue syndrome
Chronic illnesses
Concise Report
cortisol
depression
Depression - complications
Diseases of the osteoarticular system
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Estradiol - blood
fatigue
Fatigue - complications
Female
Fibromyalgia
Fibromyalgia - blood
Fibromyalgia - complications
Fibromyalgia - physiopathology
follicle stimulating hormone
Follicle Stimulating Hormone - blood
FSH
Gonadal Steroid Hormones - blood
Gonadotropins, Pituitary - blood
Hormones
HPA
HPG
Humans
Hydrocortisone - blood
hypothalamic-pituitary-adrenal
hypothalamic-pituitary-gonadal
hypothalamic-pituitary-gonadal axis
Hypothalamo-Hypophyseal System - physiopathology
Immunoassay
Inventory
luteinising hormone
Luteinizing Hormone - blood
Medical sciences
Mental depression
Nervous system (semeiology, syndromes)
Neurology
Ovary - physiopathology
Pain
Progesterone - blood
Prolactin - blood
Rheumatoid arthritis
Sleep
Sleep Wake Disorders - complications
Studies
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Summary:Objectives: To investigate abnormalities of the hypothalamic-pituitary-gonadal (HPG) axis and cortisol concentrations in young women with primary fibromyalgia (FM); and to determine whether depression, fatigue, and sleep disturbance affect these hormones. Methods: Follicle stimulating hormone (FSH), luteinising hormone (LH), oestradiol, progesterone, prolactin, and cortisol concentrations in 63 women with FM were compared with those in 38 matched healthy controls; all subjects aged
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2003.014969