Hypothalamic-pituitary-adrenal axis function in ankylosing spondylitis

Objective: To assess basal function and responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in patients with ankylosing spondylitis during dynamic testing. Methods: Insulin induced hypoglycaemia (IIH) (Actrapid HM 0.1 IU/kg, as intravenous bolus) was induced in 17 patients and 11 healthy...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2004-06, Vol.63 (6), p.671-674
Main Authors: Imrich, R, Rovensky, J, Zlnay, M, Radikova, Z, Macho, L, Vigas, M, Koska, J
Format: Article
Language:English
Subjects:
17-alpha-Hydroxyprogesterone - blood
17-OHP
17α-hydroxyprogesterone
Adrenocorticotropic Hormone - blood
Adult
ankylosing spondylitis
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Blood Glucose - analysis
Body mass index
Case-Control Studies
cortisol
Dehydroepiandrosterone Sulfate - blood
dehydroepiandrosterone sulphate
DHEAS
Diseases of the osteoarticular system
Extended Report
Female
Glucose
HPA
Humans
Hydrocortisone - blood
hypothalamic-pituitary-adrenal
hypothalamic-pituitary-adrenal axis
Hypothalamo-Hypophyseal System - physiology
IIH
Inflammatory joint diseases
Insulin - blood
insulin induced hypoglycaemia
Insulin resistance
Insulin Resistance - physiology
Interleukin-6 - blood
Male
Market shares
Medical sciences
Pituitary-Adrenal System - physiology
Rodents
Spondylitis, Ankylosing - blood
Spondylitis, Ankylosing - drug therapy
Spondylitis, Ankylosing - physiopathology
Tumor Necrosis Factor-alpha - analysis
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Summary:Objective: To assess basal function and responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in patients with ankylosing spondylitis during dynamic testing. Methods: Insulin induced hypoglycaemia (IIH) (Actrapid HM 0.1 IU/kg, as intravenous bolus) was induced in 17 patients and 11 healthy controls matched for age, sex, and body mass index. Concentrations of glucose, adrenocorticotrophic hormone (ACTH), cortisol, insulin, dehydroepiandrosterone sulphate (DHEAS), 17α-hydroxyprogesterone, interleukin 6 (IL-6), and tumour necrosis factor α (TNFα) were determined in plasma. Results: Comparable basal cortisol levels were found in the two groups, with a trend to be lower in ankylosing spondylitis. In the ankylosing spondylitis group, there were higher concentrations of IL-6 (mean (SEM): 16.6 (2.8) pg/ml v 1.41 (0.66) pg/ml in controls; p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2003.006940