Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis

Background: Early treatment prevents progression of joint damage in rheumatoid arthritis (RA), but diagnosis in early disease is impeded by lack of appropriate diagnostic criteria. Objective: To study the value of rheumatoid factor (RF), anti-cyclic citrullinated peptide autoantibodies (anti-CCP), a...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2005-12, Vol.64 (12), p.1731-1736
Main Authors: Nell, V P K, Machold, K P, Stamm, T A, Eberl, G, Heinzl, H, Uffmann, M, Smolen, J S, Steiner, G
Format: Article
Language:English
Subjects:
28 joint count Disease Activity Score
ACR
Adolescent
Adult
Aged
Aged, 80 and over
American College of Rheumatology
anti-CCP
anti-cyclic citrullinated peptide antibodies
anti-RA33
Antibodies, Antinuclear - blood
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - diagnostic imaging
autoantibodies
Autoantibodies - blood
Biomarkers - blood
Classification
DAS28
Disease
disease modifying antirheumatic drugs
Disease Progression
DMARDs
Early Diagnosis
early rheumatoid arthritis
Epidemiologic Methods
Extended Report
Humans
Immunoglobulins
Middle Aged
Peptides, Cyclic - immunology
positive predictive value
PPV
Prognosis
Radiography
receiver operating characteristics
Rheumatism
Rheumatoid arthritis
rheumatoid factor
Rheumatoid Factor - blood
Ribonucleoproteins - immunology
ROC
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Description
Summary:Background: Early treatment prevents progression of joint damage in rheumatoid arthritis (RA), but diagnosis in early disease is impeded by lack of appropriate diagnostic criteria. Objective: To study the value of rheumatoid factor (RF), anti-cyclic citrullinated peptide autoantibodies (anti-CCP), and anti-RA33 autoantibodies for diagnosis of RA and prediction of outcome in patients with very early arthritis. Methods: The prospective follow up inception cohort included 200 patients with very early (
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2005.035691