Remitting seronegative symmetrical synovitis with pitting oedema/polymyalgia rheumatica after infection with Mycoplasma pneumoniae

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) is similar to polymyalgia rheumatica (PMR) in that it shows arthralgia attributable to tenosynovitis and muscle pain, occurring most commonly in the elderly, and shows a good response to corticosteroid treatment. 1- 4 The aetio...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2005-12, Vol.64 (12), p.1797-1798
Main Authors: Matsuda, M, Shimojima, Y, Gono, T, Ishii, W, Kaneko, K, Yazaki, M, Ikeda, S-i
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antibiotics
Colds
Disease
Edema - microbiology
Female
Humans
IgM
Infections
Letter
Male
Mycoplasma pneumoniae
Pneumonia, Mycoplasma - complications
polymyalgia rheumatica
Polymyalgia Rheumatica - microbiology
remitting seronegative symmetrical synovitis with pitting oedema (RS3PE)
Rheumatism
Rheumatoid arthritis
Synovitis - microbiology
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Summary:Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) is similar to polymyalgia rheumatica (PMR) in that it shows arthralgia attributable to tenosynovitis and muscle pain, occurring most commonly in the elderly, and shows a good response to corticosteroid treatment. 1- 4 The aetiologies of RS3PE and PMR are still unknown, but they are sometimes associated with neoplastic, other rheumatic, or infectious diseases. 5, 6 Here, we report clinical findings in four patients with RS3PE or PMR, or both, after infection with Mycoplasma pneumoniae. Previous exposure to Mycoplasma species is commonly confirmed by immunoblotting in patients with rheumatoid arthritis or juvenile rheumatoid arthritis, but polymerase chain reaction showed no detectable DNA of these agents in the synovial fluid or tissue. 9 A prospective epidemiological study in Denmark indicated that the incidence of PMR varied in parallel with epidemics of M pneumoniae infection. 10 These findings indirectly suggest that Mycoplasma species may be related to the development of rheumatic disorders, and the present cases represent important direct evidence of the involvement of M pneumoniae in the aetiology of RS3PE/PMR.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2005.037390