Anti-C1q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus

Objective: To investigate antibodies to complement 1q (anti-C1q) and investigate the correlation between anti-C1q titres and renal disease in systemic lupus erythematosus (SLE). Methods: 151 SLE patients were studied. In patients with biopsy proven lupus nephritis (n = 77), activity of renal disease...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2005-03, Vol.64 (3), p.444-448
Main Authors: Marto, N, Bertolaccini, M L, Calabuig, E, Hughes, G R V, Khamashta, M A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
anti-dsDNA
antibodies against double stranded DNA
antiphospholipid syndrome
APS
autoantibodies
Autoantibodies - blood
BILAG
BILAG score
Biological and medical sciences
Biomarkers - blood
Blood
British Isles Lupus Assessment Group
Classification
Complement C1q - immunology
Enzymes
Extended Report
Female
Humans
Immunoglobulins
Kidney diseases
Lupus
Lupus Erythematosus, Systemic - immunology
Lupus Nephritis - diagnosis
Lupus Nephritis - immunology
Male
Medical records
Medical sciences
Middle Aged
nephritis
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Patients
Physiology
Predictive Value of Tests
Prognosis
Proteins
Renal failure
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
SLE
systemic lupus erythematosus
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Summary:Objective: To investigate antibodies to complement 1q (anti-C1q) and investigate the correlation between anti-C1q titres and renal disease in systemic lupus erythematosus (SLE). Methods: 151 SLE patients were studied. In patients with biopsy proven lupus nephritis (n = 77), activity of renal disease was categorised according to the BILAG renal score. Sera were tested for anti-C1q by enzyme immunoassay. Serum samples were randomly selected from 83 SLE patients who had no history of renal disease, and the positive and negative predictive value of the antibodies was studied. Results: Patients with active lupus nephritis (BILAG A or B) had a higher prevalence of anti-C1q than those with no renal disease (74% v 32%; relative risk (RR) = 2.3 (95% confidence interval, 1.6 to 3.3)) (p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2004.024943