Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis

Background: Qualitative differences in synovitis between the cartilage-pannus junction (CPJ) region and the adjoining suprapatellar pouch (SPP) have been reported in rheumatoid arthritis and the spondyloarthropathies. Objective: To determine if the distribution of synovitis is the same in osteoarthr...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the rheumatic diseases 2005-09, Vol.64 (9), p.1347-1349
Main Authors: Rhodes, L A, Conaghan, P G, Radjenovic, A, Grainger, A J, Emery, P, McGonagle, D
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Arthritis, Rheumatoid - pathology
Biological and medical sciences
Biomechanics
Cartilage, Articular - pathology
cartilage-pannus junction
Concise Report
contrast enhanced MRI
Contrast Media
CPJ
DEMRI
Disease
Diseases of the osteoarticular system
dynamic
gadolinium diethylenetriamine pentaacetic acid
Gadolinium DTPA
Gd-DTPA
Humans
Image Processing, Computer-Assisted
Immunology
Inflammatory joint diseases
initial rate of contrast enhancement
IRE
magnetic resonance imaging
Magnetic Resonance Imaging - methods
maximal enhancement
Medical sciences
MRI
NMR
Nuclear magnetic resonance
osteoarthritis
Osteoarthritis, Knee - pathology
Patella - pathology
rheumatoid arthritis
Software
SpA
SPO
spondyloarthropathies
SPP
superior pole patella osteophyte
suprapatellar pouch
Synovitis - pathology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Qualitative differences in synovitis between the cartilage-pannus junction (CPJ) region and the adjoining suprapatellar pouch (SPP) have been reported in rheumatoid arthritis and the spondyloarthropathies. Objective: To determine if the distribution of synovitis is the same in osteoarthritis (OA) using sensitive measures of inflammation derived from dynamic, contrast enhanced magnetic resonance imaging (DEMRI). Methods: 20 subjects with established OA of the knee were recruited. Conventional MR images together with the DEMRI measurements were obtained. Areas of synovitis at the CPJ region and at a distant site in the SPP were calculated; differences in CPJ and SPP synovitis were determined using DEMRI parameters: the initial rate of contrast enhancement (IRE) and maximal enhancement (ME). Results: The area of synovitis was significantly greater adjacent to the CPJ than in the SPP. IRE and ME measures were greater at the CPJ than the SPP. Conclusions: The magnitude of synovitis at the CPJ is not disease-specific and applies across the spectrum of degenerative disease as well as inflammatory diseases.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2004.033688