Enduring increased risk of developing depression and mania in patients with dementia

Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and cont...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2002-07, Vol.73 (1), p.40-44
Main Authors: Nilsson, F M, Kessing, L V, Sørensen, T M, Andersen, P K, Bolwig, T G
Format: Article
Language:English
Subjects:
affective disorder
Aged
Aged, 80 and over
Biological and medical sciences
Bipolar Disorder - etiology
Cohort Studies
Complications and side effects
Danish National Hospital Register
Danish Psychiatric Central Register
Dementia
Dementia - psychology
Depression - etiology
Depression, Mental
Development and progression
DNHR
DPCR
Female
Humans
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Poisson Distribution
Research Design
Risk
survival analysis
Time Factors
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Summary:Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.73.1.40