Immune reconstitution in HIV-1 infected subjects treated with potent antiretroviral therapy

The introduction of potent antiretroviral drug regimens contributed to a decline in HIV-1 associated morbidity and mortality. Clinical observations of spontaneous remission of previously untreatable opportunistic infections in subjects on highly active antiretroviral therapy (HAART) reflect the subs...

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Bibliographic Details
Published in:Sexually transmitted infections 1999-08, Vol.75 (4), p.218-224
Main Authors: Kaufmann, G R, Zaunders, J, Cooper, D A
Format: Article
Language:English
Subjects:
AIDS-Related Opportunistic Infections - prevention & control
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Cytokines - immunology
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1
Humans
Immunologic Memory
Interleukin-2 - therapeutic use
Lymphocyte Activation
Medical sciences
Original
Pharmacology. Drug treatments
T-Lymphocyte Subsets - immunology
Virus Replication - drug effects
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Summary:The introduction of potent antiretroviral drug regimens contributed to a decline in HIV-1 associated morbidity and mortality. Clinical observations of spontaneous remission of previously untreatable opportunistic infections in subjects on highly active antiretroviral therapy (HAART) reflect the substantial degree of immune reconstitution which can be achieved by those therapies. A biphasic increase of CD4+ T lymphocytes has been reported including naive (CD45RA+) and memory (CD45RO+) cell subsets. Proliferative lymphocyte responses to recall antigens and mitogens are enhanced over time, while T lymphocyte activation is largely reduced and T cell receptor (TCR) repertoires are partly restored. Proliferative lymphocyte responses specific to HIV-1 antigens, in contrast, remain weak. A complete normalisation of HIV-1 associated immunological alterations has not been reported so far, but the observation period of subjects on potent antiretroviral therapies is still relatively short.
ISSN:1368-4973
1472-3263
DOI:10.1136/sti.75.4.218