Increased plasma lipoprotein (a) concentrations in Behcet's disease and its relation to vascular events

Lp(a) could contribute to lipid deposition on arterial walls. [...]the recent finding that apo(a) is analogous to plasminogen suggests the possibility that Lp(a) could be the link between thrombosis and atherosclerosis. 2 3 The aim of this study was to measure the plasma concentrations of Lp(a) in p...

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Bibliographic Details
Published in:British heart journal 2000-08, Vol.84 (2), p.208-209
Main Authors: EREM, CIHANGIR, USLU, TURAN, DEGER, ORHAN, TOSUN, MEHMET, KAVGACI, HALIL
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Apolipoproteins
Arthritis
Behcet Syndrome - blood
Behcet Syndrome - pathology
Biomarkers - blood
Cardiovascular disease
Case-Control Studies
Cholesterol
Female
Heart attacks
Humans
Lipids
Lipoprotein(a) - analysis
Low density lipoprotein
Male
Middle Aged
Mortality
Plasma
Scientific Letters
Skin
Thrombosis
Triglycerides
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Summary:Lp(a) could contribute to lipid deposition on arterial walls. [...]the recent finding that apo(a) is analogous to plasminogen suggests the possibility that Lp(a) could be the link between thrombosis and atherosclerosis. 2 3 The aim of this study was to measure the plasma concentrations of Lp(a) in patients with Behcet's disease and to find relationships between Lp(a) concentrations and clinical findings including disease activity, ocular involvement, articular symptoms, skin lesions, neurologic involvement, and other lipid parameters. Scott estimated that at plasma Lp(a) concentrations of 30 mg/dl, cellular plasminogen binding of Lp(a) is reduced 20%, thereby decreasing cell fibrinolysis and promoting a procoagulant state. 4 Previously, Orem and colleagues from Turkey also reported that fluctuations of plasma Lp(a) concentrations with disease activity may be a contributing risk factor in the development of thrombogenic complications in patients with Behcet's disease. 5 In addition, in the present study, significant relations were found between Lp(a) concentrations and neurologic, articular, and ocular involvements and skin manifestations within the study group.
ISSN:1355-6037
0007-0769
1468-201X
DOI:10.1136/heart.84.2.208