HTLV-1 infections

Human T lymphotropic virus type 1 (HTLV-1) causes disabling and fatal diseases, yet there is no vaccine, no satisfactory treatment, and no means of assessing the risk of disease or prognosis in infected people. Recent research on the molecular virology and immunology of HTLV-1 shows the importance o...

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Bibliographic Details
Published in:Journal of clinical pathology 2000-08, Vol.53 (8), p.581-586
Main Author: Bangham, Charles R M
Format: Article
Language:English
Subjects:
adult T cell leukaemia/lymphoma
Adults
AIDS/HIV
Antigens
Biological and medical sciences
Blood products
Cytotoxicity
Disease
Equilibrium
Genomes
Hepatitis
HIV
HLA-A2 Antigen - immunology
HTLV-I Infections - immunology
HTLV-I Infections - virology
Human immunodeficiency virus
human T lymphotropic virus type 1
Human T-lymphotropic virus 1 - immunology
Human viral diseases
Humans
Immunology
Infections
Infectious diseases
Leader
Leukemia-Lymphoma, Adult T-Cell - immunology
Lymphocytes
Medical sciences
Mortality
myelopathy
Paraparesis, Tropical Spastic - immunology
Pathogenesis
Proteins
Proviruses - isolation & purification
tropical spastic paraparesis
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral diseases of the nervous system
Viral infections
Viral Load
Virology
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Description
Summary:Human T lymphotropic virus type 1 (HTLV-1) causes disabling and fatal diseases, yet there is no vaccine, no satisfactory treatment, and no means of assessing the risk of disease or prognosis in infected people. Recent research on the molecular virology and immunology of HTLV-1 shows the importance of the host's immune response in reducing the risk of these diseases, and is beginning to explain why some HTLV-1 infected people develop serious illnesses whereas most remain healthy life long carriers of the virus. These findings might be applicable to other persistent virus infections such as human immunodeficiency virus, hepatitis B, and hepatitis C.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.53.8.581