Prefrontal repetitive transcranial magnetic stimulation as add on treatment in depression

A growing number of studies report antidepressant effects of repetitive transcranial magnetic stimulation (rTMS) in patients with major depression. The hypothesis that high frequency (20 Hz) rTMS (HF-rTMS) may speed up and strengthen the therapeutic response to sertraline in MD was tested. Twenty ei...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2001-10, Vol.71 (4), p.546-548
Main Authors: García-Toro, M, Pascual-Leone, A, Romera, M, González, A, Micó, J, Ibarra, O, Arnillas, H, Capllonch, I, Mayol, A, Tormos, J M
Format: Article
Language:English
Subjects:
Adult
Alternative medicine
Antidepressants
Biological and medical sciences
Brain stimulation
Care and treatment
Combined Modality Therapy
Depression, Mental
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - therapy
Diseases of the nervous system
Electric Stimulation Therapy
Electromagnetic Fields
Female
Health aspects
Humans
Magnetic fields
major depression
Male
Medical sciences
Mental depression
Middle Aged
Patients
prefrontal area
Prefrontal Cortex - physiopathology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
sertraline
Sertraline - administration & dosage
Short Report
Transcranial magnetic stimulation
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Summary:A growing number of studies report antidepressant effects of repetitive transcranial magnetic stimulation (rTMS) in patients with major depression. The hypothesis that high frequency (20 Hz) rTMS (HF-rTMS) may speed up and strengthen the therapeutic response to sertraline in MD was tested. Twenty eight patients who had not yet received medication for the present depressive episode (n=12) or had failed a single trial of an antidepressant medication (n=16) were started on sertraline and randomised to receive either real of sham HF-rTMS. HF-rTMS was applied to the left dorsolateral prefrontal area in daily sessions (30 trains of 2 s, 20–40 s intertrain interval, at 90% motor threshold) on 10 consecutive working days. The results suggest that in this patient population, HF-rTMS does not add efficacy over the use of standard antidepressant medication.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.71.4.546