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A Droplet-Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor-Diffusion Methods with On-Chip X-Ray Diffraction

On‐chip protein crystallization and diffraction: Proteins can be crystallized in nanoliter volumes by using both microbatch and vapor‐diffusion techniques inside composite PDMS/glass microfluidic devices (PDMS=polydimethylsiloxane). The quality of crystals can be assessed directly by on‐chip X‐ray d...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-05, Vol.43 (19), p.2508-2511
Main Authors: Zheng, Bo, Tice, Joshua D., Roach, L. Spencer, Ismagilov, Rustem F.
Format: Article
Language:English
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Summary:On‐chip protein crystallization and diffraction: Proteins can be crystallized in nanoliter volumes by using both microbatch and vapor‐diffusion techniques inside composite PDMS/glass microfluidic devices (PDMS=polydimethylsiloxane). The quality of crystals can be assessed directly by on‐chip X‐ray diffraction (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200453974