Oncostatin M in the anti-inflammatory response

Oncostatin M (OM) is a pleiotropic cytokine of the interleukin 6 family, whose in vivo properties and physiological function remain in dispute and poorly defined. These in vivo studies strongly suggest that OM is anabolic, promoting wound healing and bone formation, and anti-inflammatory. In models...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2001-11, Vol.60 (suppl 3), p.iii75-iii80
Main Authors: Wahl, A F, Wallace, P M
Format: Article
Language:English
Subjects:
Animals
Arthritis
Arthritis, Experimental - drug therapy
Bacterial Infections - metabolism
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Clinical trials
Cytokines
Disease
Humans
Infections
Inflammation
Inflammation Mediators - physiology
Inflammatory diseases
Lipopolysaccharides
Medical sciences
Mice
Models, Animal
Multiple Sclerosis - drug therapy
Oncostatin M
Peptides - physiology
Peptides - therapeutic use
Pharmacology. Drug treatments
Proteins
Rodents
Tumor Necrosis Factor-alpha - metabolism
Wound healing
Wound Healing - physiology
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Summary:Oncostatin M (OM) is a pleiotropic cytokine of the interleukin 6 family, whose in vivo properties and physiological function remain in dispute and poorly defined. These in vivo studies strongly suggest that OM is anabolic, promoting wound healing and bone formation, and anti-inflammatory. In models of inflammation OM is produced late in the cytokine response and protects from lipopolysaccharide (LPS)-induced toxicities, promoting the re-establishment of homoeostasis by cooperating with proinflammatory cytokines and acute phase molecules to alter and attenuate the inflammatory response. Administration of OM inhibited bacterial LPS-induced production of tumour necrosis factor α and septic lethality in a dose dependent manner. Consistent with these findings, in animal models of chronic inflammatory disease OM potently suppressed inflammation and tissue destruction in murine models of rheumatoid arthritis and multiple sclerosis. T cell function and antibody production were not impaired by OM treatment. Taken together, these data indicate that the activities of this cytokine in vivo are anti-inflammatory without concordant immunosuppression.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.60.90003.iii75