Balancing the immune system: Th1 and Th2

[...]immune responses to hsps can be viewed as a secondary event, reflecting tissue breakdown and release of intracellular proteins after any pathological disturbance (necrosis). The selective upregulation of hsp at sites of inflammation, attibutable to cellular stress caused by the locally produced...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the rheumatic diseases 2002-11, Vol.61 (suppl 2), p.ii25-28
Main Authors: van Eden, W, van der Zee, R, van Kooten, P, Berlo, S E, Cobelens, P M, Kavelaars, A, Heijnen, C J, Prakken, B, Roord, S, Albani, S
Format: Article
Language:English
Subjects:
Animals
Antigens
Arthritis
Arthritis - immunology
Autoimmune diseases
Autoimmunity
Biological and medical sciences
Cytokines
Cytokines - immunology
Diabetes
Disease
Diseases of the osteoarticular system
Experiments
heat shock protein
Heat shock proteins
Heat-Shock Proteins - immunology
hsp
Humans
Immune system
Immune Tolerance
Immunity, Mucosal
immunology
Inflammation
Inflammatory joint diseases
Lymphocytes
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
T cells
Th1 Cells - immunology
Th2 Cells - immunology
TLR
Toll-like receptor
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[...]immune responses to hsps can be viewed as a secondary event, reflecting tissue breakdown and release of intracellular proteins after any pathological disturbance (necrosis). The selective upregulation of hsp at sites of inflammation, attibutable to cellular stress caused by the locally produced toxic proinflammatory mediators, is possibly essential for the function of host hsp to attract such regulatory T cells and to let them exert their regulation. [...]in children with chronic arthritis (JIA) T cell responses to human hsp60 have been seen to coincide with disease remission. 6, 7 These observations and others have now led to the initiation of clinical trials using selected hsp peptides as an immuno-intervention (therapeutic vaccine) in diabetes and rheumatoid arthritis. 8, 9 In rat adjuvant arthritis and avridine induced arthritis, we have recently identified the induction of IL10 producing T cells upon hsp immunisation as one of the inflammation suppressive mechanisms.\n Altogether, it seems that both at the side of innate and at the side of adaptive immunity, contact with microbial antigens in the gut contributes to the development of a tolerant state towards the microflora.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.61.suppl_2.ii25