Decreased serum vascular endothelial growth factor concentrations in patients with congestive heart failure

Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and has been reported to promote collateral formation in ischaemic cardiac muscle and tissue repair after wounding. 1 In animal models, transfer of the VEGF gene into ischaemic limbs induces angiogenesis and improve...

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Bibliographic Details
Published in:British heart journal 2003-02, Vol.89 (2), p.207-208
Main Authors: Arakawa, H, Ikeda, U, Hojo, Y, Ueno, S, Nonaka-Sarukawa, M, Yamamoto, K, Shimada, K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiogenesis
Anticoagulants
BNP
brain natriuretic peptide
Cardiac patients
Cardiology
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Case studies
Causes of
CHF
Congestive heart failure
Endothelial growth factors
Endothelial Growth Factors - blood
Endothelial Growth Factors - deficiency
Enzymes
Female
Health aspects
Heart attacks
Heart failure
Heart Failure - blood
Heart Failure - etiology
Humans
Intercellular Signaling Peptides and Proteins - blood
Intercellular Signaling Peptides and Proteins - deficiency
left ventricular ejection fraction
LVEF
Lymphokines - blood
Lymphokines - deficiency
Male
Medical examination
Middle Aged
Pathogenic microorganisms
Physiological aspects
Rodents
Scientific Letters
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
VEGF
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Summary:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and has been reported to promote collateral formation in ischaemic cardiac muscle and tissue repair after wounding. 1 In animal models, transfer of the VEGF gene into ischaemic limbs induces angiogenesis and improves tissue perfusion. 2 Recently, Baumgartner and colleagues 3 demonstrated that intramuscular injection of naked plasmid DNA encoding VEGF improved limb ischaemia by promoting angiogenesis in patients with critical peripheral arterial disease. [...]decreased serum VEGF concentrations were found in CHF patients.
ISSN:1355-6037
0007-0769
1468-201X
DOI:10.1136/heart.89.2.207