Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis

Objectives: To assess the efficacy of the administration of magnesium as a method for the prevention of postoperative atrial fibrillation (AF) and to evaluate its influence on hospital length of stay (LOS) and mortality. Methods: Literature search and meta-analysis of the randomised control studies...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 2005-05, Vol.91 (5), p.618-623
Main Authors: Miller, S, Crystal, E, Garfinkle, M, Lau, C, Lashevsky, I, Connolly, S J
Format: Article
Language:English
Subjects:
Anti-Arrhythmia Agents - therapeutic use
atrial fibrillation
Atrial Fibrillation - mortality
Atrial Fibrillation - prevention & control
Biological and medical sciences
CABG
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Cardiovascular Medicine
CENTRAL
Clinical trials
Cochrane Central Register of Controlled Trials
confidence interval
coronary artery bypass graft
Drug dosages
Heart
Heart surgery
Hospital costs
Humans
Length of Stay
LOS
Magnesium
Magnesium Sulfate - therapeutic use
Medical sciences
Meta-analysis
Mortality
odds ratio
Postoperative Complications - mortality
Postoperative Complications - prevention & control
Randomized Controlled Trials as Topic
Stroke
Studies
surgery
Thoracic Surgical Procedures - mortality
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Summary:Objectives: To assess the efficacy of the administration of magnesium as a method for the prevention of postoperative atrial fibrillation (AF) and to evaluate its influence on hospital length of stay (LOS) and mortality. Methods: Literature search and meta-analysis of the randomised control studies published since 1966. Results: 20 randomised trials were identified, enrolling a total of 2490 patients. Study sample size varied between 20 and 400 patients. Magnesium administration decreased the proportion of patients developing postoperative AF from 28% in the control group to 18% in the treatment group (odds ratio 0.54, 95% confidence interval (CI) 0.38 to 0.75). Data on LOS were available from seven trials (1227 patients). Magnesium did not significantly affect LOS (weighted mean difference −0.07 days of stay, 95% CI −0.66 to 0.53). The overall mortality was low (0.7%) and was not affected by magnesium administration (odds ratio 1.22, 95% CI 0.39 to 3.77). Conclusion: Magnesium administration is an effective prophylactic measure for the prevention of postoperative AF. It does not significantly alter LOS or in-hospital mortality.
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.2004.033811