Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis

This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acu...

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Bibliographic Details
Published in:Journal of clinical pathology 2002-02, Vol.55 (2), p.152-153
Main Authors: Baidoshvili, A, Nijmeijer, R, Lagrand, W K, Hack, C E, Niessen, H W M
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
C reactive protein
C-Reactive Protein - analysis
Cholecystectomy
complement
CRP
Development and progression
Fatal Outcome
Female
Heart attacks
Human bacterial diseases
Humans
Hypotheses
infarcted tissue
Infarction - metabolism
Infectious diseases
Kidney - blood supply
Kidneys
Ligands
Liver
Liver - blood supply
Localization
Medical sciences
Middle Aged
Miscellaneous
Monoclonal antibodies
Multiple organ failure
Physiological aspects
Proteins
Sepsis
Sepsis - metabolism
Short Reports
Stains & staining
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Summary:This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.55.2.152