CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis

Aims: Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in conf...

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Bibliographic Details
Published in:Journal of clinical pathology 2002-05, Vol.55 (5), p.391-392
Main Authors: Sumathi, V P, McCluggage, W G
Format: Article
Language:English
Subjects:
Antigen-antibody reactions
Biological and medical sciences
Biomarkers - analysis
CD10
Cervix
Cicatrix - metabolism
Cysts
Diagnosis
Endometriosis
Endometriosis - diagnosis
Female
Female genital diseases
Female Urogenital Diseases - diagnosis
Genital system. Mammary gland
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Immunohistochemistry - methods
Intestinal Diseases - diagnosis
Investigative techniques, diagnostic techniques (general aspects)
Leukemia
Medical sciences
Methods
Neprilysin - analysis
Non tumoral diseases
Ovaries
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Peritoneal Diseases - diagnosis
Sarcoma
Short Reports
Stromal Cells - metabolism
Tumors
Uterus
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Summary:Aims: Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis. Methods/Results: Twenty five cases of endometriosis were stained with a commercially available antibody against CD10. Endometrial stromal cells were positive in 22 of 25 cases. There was little or no staining of other tissues. Conclusions: CD10 immunoreactivity is largely maintained in endometrial stromal cells located outside the uterus. Immunohistochemical staining with CD10 may be of value in confirming a diagnosis of endometriosis when there is morphological doubt.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.55.5.391