Fatal disseminated toxoplasmosis in a toxoplasma seropositive liver transplant recipient

Disseminated toxoplasmosis is a severe disease with a very high mortality rate, but treatment with pyrimethamine sulfadiazine or clindamycin can sometimes be effective. 1 It occurs very rarely after liver transplantation, 2- 5 and can result from primary infection or reactivation, as in our patient....

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical pathology 2002-08, Vol.55 (8), p.637-637
Main Authors: Wendum, D, Carbonell, N, Svrcek, M, Chazouilléres, O, Fléjou, J-F
Format: Article
Language:English
Subjects:
bronchoalveolar lavage fluid
Correspondence
Cysts
Fatal Outcome
Humans
Immunocompromised Host
Immunoglobulins
Infections
Liver cirrhosis
Liver Transplantation
Middle Aged
Mortality
Opportunistic Infections - immunology
Patients
toxoplasmosis
Toxoplasmosis - immunology
Transplants & implants
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Disseminated toxoplasmosis is a severe disease with a very high mortality rate, but treatment with pyrimethamine sulfadiazine or clindamycin can sometimes be effective. 1 It occurs very rarely after liver transplantation, 2- 5 and can result from primary infection or reactivation, as in our patient. Immunostaining of tissues dramatically improves toxoplasma detection. 7 The polymerase chain reaction (PCR) can also be performed on BAL fluid or blood samples. 8 The use of both morphology and PCR improves the sensitivity of the diagnosis. 7 Figure 1 Toxoplasmic pneumonitis: toxoplasmic pseudocyst (arrow) and free tachyzoites (arrowheads).
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.55.8.637