Guidelines for processing and reporting of prostatic needle biopsies

The reported detection rate of prostate cancer, lesions suspicious for cancer, and prostatic intraepithelial neoplasia (PIN) in needle biopsies is highly variable. In part, technical factors, including the quality of the biopsies, the tissue processing, and histopathological reporting, may account f...

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Bibliographic Details
Published in:Journal of clinical pathology 2003-05, Vol.56 (5), p.336-340
Main Authors: van der Kwast, Th H, Lopes, C, Santonja, C, Pihl, C-G, Neetens, I, Martikainen, P, Di Lollo, S, Bubendorf, L, Hoedemaeker, R F
Format: Article
Language:English
Subjects:
Antigens
Biological and medical sciences
Biopsy
Biopsy, Needle - methods
Biopsy, Needle - standards
ERSPC
European Randomised Study of Screening for Prostate Cancer
Genital system. Mammary gland
histopathology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Laboratories
Male
Medical sciences
needle biopsy
Nephrology. Urinary tract diseases
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
PIN
Prostate
Prostate cancer
prostate specific antigen
prostatic intraepithelial neoplasia
Prostatic Intraepithelial Neoplasia - pathology
Prostatic Neoplasms - pathology
PSA
Quality Control
Reviews
Severity of Illness Index
tissue processing
Tumors of the urinary system
Urinary tract. Prostate gland
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Description
Summary:The reported detection rate of prostate cancer, lesions suspicious for cancer, and prostatic intraepithelial neoplasia (PIN) in needle biopsies is highly variable. In part, technical factors, including the quality of the biopsies, the tissue processing, and histopathological reporting, may account for these differences. It has been thought that standardisation of tissue processing might reduce the observed variations in detection rate. Consensus among the members of the pathology committee of the European Randomised study of Screening for Prostate Cancer (ERSPC) concerning the optimal methodology of tissue embedding resulting in guidelines for prostatic needle biopsy processing was reached. The adoption of an unequivocal and uniform way of reporting lesions encountered in prostatic needle biopsies is considered helpful for decision taking by the clinician. The definition of parameters for quality control of prostatic needle biopsy diagnostics will further facilitate clinical epidemiological multicentre studies of prostate cancer.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.56.5.336