HPV and histological status of pelvic lymph node metastases in cervical cancer: a prospective study

Aims: The purpose of this prospective study was to describe the incidence and distribution pattern of human papillomavirus (HPV) DNA in intraoperative dissected lymph nodes and to relate this to the pathological confirmation of metastasis. Methods: Samples of primary cervical cancer lesions and diss...

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Bibliographic Details
Published in:Journal of clinical pathology 2004-05, Vol.57 (5), p.472-476
Main Authors: Lukaszuk, K, Liss, J, Wozniak, I, Sliwinski, W, Emerich, J, Wojcikowski, C
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cervical cancer
CIP
common iliac and para-aortic
DNA, Viral - analysis
EIO
external iliac and obturator
Female
HPV
human papillomavirus
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lymphatic Metastasis
Medical sciences
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Original
Papillomaviridae - isolation & purification
Papillomavirus Infections - complications
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
PCR
Pelvis
polymerase chain reaction
Prospective Studies
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
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Summary:Aims: The purpose of this prospective study was to describe the incidence and distribution pattern of human papillomavirus (HPV) DNA in intraoperative dissected lymph nodes and to relate this to the pathological confirmation of metastasis. Methods: Samples of primary cervical cancer lesions and dissected lymph nodes were obtained from women undergoing surgical treatment. The presence of HPV DNA was detected by the polymerase chain reaction. Results: Tissue from 79 tumours and 365 lymph nodes was analysed. Metastasis to the lymph nodes was found in 19 cases. Metastasis correlated with the volume of the primary lesion, the depth of cervical and vaginal invasion, and with invasion of the corpus. HPV DNA was found in 60 of the primary lesions and 31 of the lymph nodes. The presence of HPV DNA in the lymph nodes correlated with the volume of the primary lesion and vaginal invasion. Conclusions: The incidence of HPV DNA in lymph nodes is twice as high as that of histopathologically confirmed metastases. The risk of the presence of HPV DNA and histopathologically confirmed metastases in lymph nodes is related to certain features of the primary tumour.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2003.009852