Langerhans cell histiocytosis in sequential discordant lymphoma

B cell non-Hodgkin lymphoma of the follicular subtype (grade 3/3) affecting the nasopharynx and breast, and containing foci of Langerhans cell histiocytosis, was diagnosed in a 56 year old white woman who was a longstanding heavy smoker. Four years before this she had developed stage 1a mixed cellul...

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Bibliographic Details
Published in:Journal of clinical pathology 2005-01, Vol.58 (1), p.104-106
Main Authors: Adu-Poku, K, Thomas, D W, Khan, M K, Holgate, C S, Smith, M E F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone marrow
breast
Breast Neoplasms - complications
Breast Neoplasms - pathology
Case Reports/Short Reports
Chemotherapy
discordant lymphoma
Female
Gangrene
Hematologic and hematopoietic diseases
Histiocytosis, Langerhans-Cell - etiology
Histiocytosis, Langerhans-Cell - pathology
Hodgkin Disease - complications
Hodgkin Disease - pathology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Langerhans cell
lymph node
Lymphatic system
Lymphoma
Lymphoma, B-Cell - complications
Lymphoma, B-Cell - pathology
Lymphoma, Follicular - complications
Lymphoma, Follicular - pathology
Medical sciences
Middle Aged
Nasopharyngeal Neoplasms - complications
Nasopharyngeal Neoplasms - pathology
nasopharynx
Neoplasms, Second Primary - complications
Neoplasms, Second Primary - pathology
Other diseases. Hematologic involvement in other diseases
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Radiation therapy
Tomography
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Description
Summary:B cell non-Hodgkin lymphoma of the follicular subtype (grade 3/3) affecting the nasopharynx and breast, and containing foci of Langerhans cell histiocytosis, was diagnosed in a 56 year old white woman who was a longstanding heavy smoker. Four years before this she had developed stage 1a mixed cellularity Hodgkin lymphoma affecting the right inguinal region, which was treated by irradiation and chemotherapy without recurrence. Review of the original Hodgkin lymphoma histology demonstrated a small focus of Langerhans cell histiocytosis. This is thought to be the first recorded case of Langerhans cell histiocytosis occurring in a sequential discordant lymphoma. Its importance is discussed.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2003.015537