Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma

Aim: To investigate plasma indices of vascular permeability (vascular endothelial growth factor, VEGF—also an index of angiogenesis, as well as the soluble receptor for VEGF, sFlt-1) and endothelial damage/dysfunction (von Willebrand factor, vWf) in glaucoma. Methods: Citrated plasma was assayed for...

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Bibliographic Details
Published in:British journal of ophthalmology 2002-11, Vol.86 (11), p.1299-1302
Main Authors: Lip, P L, Felmeden, D C, Blann, A D, Matheou, N, Thakur, S, Cunliffe, I A, Lip, G Y H
Format: Article
Language:English
Subjects:
Aged
Angiogenesis
Biological and medical sciences
Capillary Permeability
Cross-Sectional Studies
Diabetes
Diabetic retinopathy
Disease
Endothelial Growth Factors - analysis
Endothelium
Eye and associated structures. Visual pathways and centers. Vision
Female
Fundamental and applied biological sciences. Psychology
Glaucoma
Glaucoma - blood
Glaucoma - physiopathology
Glaucoma and intraocular pressure
Hormone replacement therapy
Hospitals
Humans
Hypothesis testing
Intercellular Signaling Peptides and Proteins - analysis
Laboratories
Laboratory Science
Lymphokines - analysis
Male
Medical sciences
Middle Aged
Ophthalmology
Optic nerve
Pathogenesis
Permeability
Physiological aspects
Plasma
R&D
Regression Analysis
Research & development
Standard deviation
Variance analysis
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-1 - analysis
Vascular Endothelial Growth Factors
vascular permeability
Veins & arteries
Vertebrates: nervous system and sense organs
Von Willebrand factor
von Willebrand Factor - analysis
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Summary:Aim: To investigate plasma indices of vascular permeability (vascular endothelial growth factor, VEGF—also an index of angiogenesis, as well as the soluble receptor for VEGF, sFlt-1) and endothelial damage/dysfunction (von Willebrand factor, vWf) in glaucoma. Methods: Citrated plasma was assayed for VEGF, sFlt-1, and vWf (all ELISA) in a cross sectional study of 50 patients (20 male; mean age 63.9 years, SD 10.5) with glaucoma: 26 had normal tension glaucoma (NTG) and 24 had primary open angle glaucoma (POAG), who were compared with 26 healthy controls (mean age 73.4 years, SD 9.2). Results: Median (interquartile range, IQR) levels of VEGF were significantly elevated in patients with NTG and POAG compared to healthy controls (Kruskal-Wallis test, p
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.86.11.1299