In vitro and in vivo study of lens refilling with poloxamer hydrogel

Aim: To evaluate the compatibility of poloxamer hydrogel as a material for an injectable intraocular lens, in vivo and in vitro. Methods: The appropriate concentration of poloxamer hydrogel was determined for injection by examining the transparency and gelling temperature of this material, assessing...

Full description

Saved in:
Bibliographic Details
Published in:British journal of ophthalmology 2003-11, Vol.87 (11), p.1399-1402
Main Authors: Han, Y K, Kwon, J W, Kim, J S, Cho, C-S, Wee, W R, Lee, J H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biophysical Phenomena
Biophysics
Body temperature
Cataract Extraction
Hydrogels
Hydrogels - administration & dosage
injectable intraocular lens
Injections
Laboratory Science - Extended Reports
lens refilling
Lenses, Intraocular
Male
Medical sciences
Molecular weight
Poloxamer - administration & dosage
poloxamer hydrogel
Prevention
rabbit model
Rabbits
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the eye and orbit
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim: To evaluate the compatibility of poloxamer hydrogel as a material for an injectable intraocular lens, in vivo and in vitro. Methods: The appropriate concentration of poloxamer hydrogel was determined for injection by examining the transparency and gelling temperature of this material, assessing the lens capsule refilling technique, and studying the postoperative findings in a rabbit model. Results: Poloxamer hydrogel showed excellent transparency and 25% was identified as an appropriate concentration for the lens refilling material. The authors developed a technique for injecting the material in vivo and obtained excellent short term results. Conclusions: Poloxamer hydrogel was identified as an appropriate material for direct lens refilling, and the developed injection technique produced excellent short term results.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.87.11.1399