Influence of non-penetrating glaucoma surgery on aqueous outflow facility in isolated porcine eyes

• Published in: British journal of ophthalmology 2004-07, Vol.88 (7), p.950-952
• Main Authors: Shaarawy, T, Wu, R, Mermoud, A, Flammer, J, Haefliger, I O
• Format: Article
• Language: English
• Subjects: Animals; Anterior Chamber - surgery; aqueous; Aqueous Humor - physiology; Biological and medical sciences; Catheters; deep sclerectomy; Eye Enucleation - methods; Glaucoma; Glaucoma - physiopathology; Glaucoma - surgery; Glaucoma and intraocular pressure; intraocular pressure; IOP; Laboratory Science - Scientific Reports; Medical sciences; non-penetrating; non-penetrating glaucoma surgery; NPGS; Ophthalmology; Postoperative period; Sclera - surgery; Studies; Surgery; Surgical Flaps; Sutures; Swine; TDM; trabeculo-Descemet’s membrane; viscocanalostomy
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.2003.035535

Purpose: To investigate, in vitro, the influence of non-penetrating glaucoma surgery (NPGS) and the influence of tightly suturing the superficial scleral flap on the aqueous outflow facility of isolated porcine eyes. Materials and methods: The anterior chambers of 12 enucleated porcine cadaver eyes were cannulated and perfused. NPGS was performed by the same surgeon. The overall ocular aqueous outflow facilities were assessed before and after the surgical interventions of NPGS, as well as after scleral flap closure. Results: The mean (SD) aqueous outflow facility, which was 0.164 (0.014) μl/min/mm Hg before surgery, increased significantly after NPGS to 1.584 (0.217) μl/min/mm Hg, p